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letter
. 1971 Sep;43(1):255–257. doi: 10.1111/j.1476-5381.1971.tb07177.x

Effect of 6-hydroxydopamine on electrical self stimulation of the brain

G R Breese, J L Howard, J P Leahy
PMCID: PMC1665933  PMID: 5136461

Abstract

In rats, after a single intracisternal injection of 6-hydroxydopamine (6-OHDA) electrical self stimulation was reduced by approximately 50%. The concentrations of noradrenaline and dopamine in the brain were reduced by 83%. A second injection of 6-OHDA reduced the concentration of these amines to 7% of control values and virtually eliminated self stimulation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANTON A. H., SAYRE D. F. A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines. J Pharmacol Exp Ther. 1962 Dec;138:360–375. [PubMed] [Google Scholar]
  2. ANTON A. H., SAYRE D. F. THE DISTRIBUTION OF DOPAMINE AND DOPA IN VARIOUS ANIMALS AND A METHOD FOR THEIR DETERMINATION IN DIVERSE BIOLOGICAL MATERIAL. J Pharmacol Exp Ther. 1964 Sep;145:326–336. [PubMed] [Google Scholar]
  3. Bloom F. E., Algeri S., Groppetti A., Revuelta A., Costa E. Lesions of central norepinephrine terminals with 6-OH-dopamine: biochemistry and fine structure. Science. 1969 Dec 5;166(3910):1284–1286. doi: 10.1126/science.166.3910.1284. [DOI] [PubMed] [Google Scholar]
  4. Breese G. R., Traylor T. D. Effect of 6-hydroxydopamine on brain norepinephrine and dopamine evidence for selective degeneration of catecholamine neurons. J Pharmacol Exp Ther. 1970 Sep;174(3):413–420. [PMC free article] [PubMed] [Google Scholar]
  5. Burkard W. P., Jalfre M., Blum J. Effect of 6-hydroxydopamine on behaviour and cerebral amine content in rats. Experientia. 1969 Dec 15;25(12):1295–1296. doi: 10.1007/BF01897508. [DOI] [PubMed] [Google Scholar]
  6. Evetts K. D., Uretsky N. J., Iversen L. L., Iversen S. D. Effects of 6-hydroxydopamine on CNS catecholamines, spontaneous motor activity and amphetamine induced hyperactivity in rats. Nature. 1970 Mar 7;225(5236):961–962. doi: 10.1038/225961a0. [DOI] [PubMed] [Google Scholar]
  7. HAEGGENDAL J. AN IMPROVED METHOD FOR FLUORIMETRIC DETERMINATION OF SMALL AMOUNTS OF ADRENALINE AND NORADRENALINE IN PLASMA AND TISSUES. Acta Physiol Scand. 1963 Nov;59:242–254. doi: 10.1111/j.1748-1716.1963.tb02739.x. [DOI] [PubMed] [Google Scholar]
  8. POSCHEL B. P., NINTEMAN F. W. NOREPINEPHRINE: A POSSIBLE EXCITATORY NEUROHORMONE OF THE REWARD SYSTEM. Life Sci. 1963 Oct;10:782–788. doi: 10.1016/0024-3205(63)90087-0. [DOI] [PubMed] [Google Scholar]
  9. Poschel B. P., Ninteman F. W. Hypothalamic self-stimulation: its suppression by blockade of norepinephrine biosynthesis and reinstatement by methamphetamine. Life Sci. 1966 Jan;5(1):11–16. doi: 10.1016/0024-3205(66)90181-0. [DOI] [PubMed] [Google Scholar]
  10. Roll S. K. Intracranial self-stimulation and wakefulness: effect of manipulating ambient brain catecholamines. Science. 1970 Jun 12;168(3937):1370–1372. doi: 10.1126/science.168.3937.1370. [DOI] [PubMed] [Google Scholar]
  11. Stein L., Wise C. D. Release of norepinephrine from hypothalamus and amygdala by rewarding medial forebrain bundle stimulation and amphetamine. J Comp Physiol Psychol. 1969 Feb;67(2):189–198. doi: 10.1037/h0026767. [DOI] [PubMed] [Google Scholar]
  12. Uretsky N. J., Iversen L. L. Effects of 6-hydroxydopamine on catecholamine containing neurones in the rat brain. J Neurochem. 1970 Feb;17(2):269–278. doi: 10.1111/j.1471-4159.1970.tb02210.x. [DOI] [PubMed] [Google Scholar]
  13. Wise C. D., Stein L. Facilitation of brain self-stimulation by central administration of norepinephrine. Science. 1969 Jan 17;163(3864):299–301. doi: 10.1126/science.163.3864.299. [DOI] [PubMed] [Google Scholar]

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