Abstract
Rats that were subjected to restraint stress for 18 h were found to have reduced myocardial glycogen and blood sugar levels and showed histological changes in heart and adrenals. The effects of α-methyl-p-tyrosine, α-methyl-dopa, disulfiram and actinomycin D on these stress-induced changes were examined. Of these drugs, only α-methyl-p-tyrosine was able to prevent the fall in myocardial glycogen and blood sugar and none of the drugs prevented the histological changes induced by stress.
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- HESS S. M., CONNAMACHER R. H., OZAKI M., UDENFRIEND S. The effects of alpha-methyl-DOPA and alpha-methyl-metatyrosine on the metabolism of norepinephrine and serotonin in vivo. J Pharmacol Exp Ther. 1961 Nov;134:129–138. [PubMed] [Google Scholar]
- KEMP A., VAN HEIJNINGEN A. J. M. K. A colorimetric micro-method for the determination of glycogen in tissues. Biochem J. 1954 Apr;56(4):646–648. doi: 10.1042/bj0560646. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Maître L. Presence of alpha-methyl-DOPA metabolites in heart and brain of guinea pigs treated with alpha-methyl-tyrosine. Life Sci. 1965 Dec;4(23):2249–2256. doi: 10.1016/0024-3205(65)90245-6. [DOI] [PubMed] [Google Scholar]
- Musacchio J. M., Goldstein M., Anagnoste B., Poch G., Kopin I. J. Inhibition of dopamine-beta-hydroxylase by disulfiram in vivo. J Pharmacol Exp Ther. 1966 Apr;152(1):56–61. [PubMed] [Google Scholar]
- RAAB W., STARK E., MACMILLAN W. H., GIGEE W. R. Sympathogenic origin and antiadrenergic prevention of stress-induced myocardial lesions. Am J Cardiol. 1961 Aug;8:203–211. doi: 10.1016/0002-9149(61)90207-7. [DOI] [PubMed] [Google Scholar]
- RENAUD S. Improved restraint-technique for producing stress and cardiac necrosis in rats. J Appl Physiol. 1959 Sep;14:868–869. doi: 10.1152/jappl.1959.14.5.868. [DOI] [PubMed] [Google Scholar]
- SMOGYI M. Notes on sugar determination. J Biol Chem. 1952 Mar;195(1):19–23. [PubMed] [Google Scholar]
- Sharma V. N., Parmar N. S. Effect of chlorpromazine, mecamylamine and guanethidine on the cold stress induced changes in myocardial glycogen and acetylcholine content in rabbits. Indian J Med Res. 1967 Jan;55(1):60–72. [PubMed] [Google Scholar]