Abstract
1. The respiration of a mitochondrial and synaptasome fraction of rat cerebral cortex was measured using an oxygen electrode.
2. Little or no enhancement of oxygen uptake occurred on separately adding formyl tetrahydrofolate or noradrenaline.
3. When these substances were added together a marked increase in respiration was observed.
4. Both phenobarbitone and phenytoin inhibited the respiration of this preparation, but this was reversed on the addition of formyl tetrahydrofolate.
5. The possibility that some antiepileptic drugs may compete with formyl tetrahydrofolate in the brain is considered and structural similarities between folic acid and these drugs are indicated.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BADENOCH J. The megaloblastic anaemias. Postgrad Med J. 1954 Feb;30(340):87–92. doi: 10.1136/pgmj.30.340.87. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dennis J., Taylor D. C. Epilepsy and folate deficiency. Br Med J. 1969 Dec 27;4(5686):807–808. doi: 10.1136/bmj.4.5686.807-d. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ginsborg B. L., Hirst G. D. Cyclic AMP, transmitter release and the effect of adenosine on neuromuscular transmission. Nat New Biol. 1971 Jul 14;232(28):63–64. doi: 10.1038/newbio232063a0. [DOI] [PubMed] [Google Scholar]
- HAWKINS C. F., MEYNELL M. J. Megaloblastic anaemia due to phenytoin sodium. Lancet. 1954 Oct 9;267(6841):737–738. doi: 10.1016/s0140-6736(54)90499-7. [DOI] [PubMed] [Google Scholar]
- Palmer G. C., Robison G. A., Sulser F. Modification by spychotropic drugs of the cyclic adenosine monophosphate response to norepinephrine in rat brain. Biochem Pharmacol. 1971 Jan;20(1):236–239. doi: 10.1016/0006-2952(71)90491-6. [DOI] [PubMed] [Google Scholar]
- Spector R. G. Folic acid and convulsions in the rat. Biochem Pharmacol. 1971 Jul;20(7):1730–1732. doi: 10.1016/0006-2952(71)90310-8. [DOI] [PubMed] [Google Scholar]