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. 1972 Sep;46(1):172–175. doi: 10.1111/j.1476-5381.1972.tb06861.x

Prostaglandin biosynthesis by human skin and its inhibition by corticosteroids

M W Greaves, Wendy McDonald-Gibson
PMCID: PMC1666109  PMID: 5084821

Abstract

Homogenates of human breast skin form prostaglandins E2 and F2α in the presence of arachidonic acid substrate. Significant inhibition of biosynthesis of prostaglandin E2 and F2α was observed in the presence of the anti-inflammatory corticosteroid fluocinolone acetonide. This effect was dose-related. By contrast no significant inhibition was observed in the presence of an approximately equimolar concentration of hydrocortisone.

Since prostaglandins have been recovered from several types of inflammatory reactions and are capable of mediating most of the components of inflammation the possibility arises that corticosteroids may owe their anti-inflammatory activity at least in part to inhibition of prostaglandin biosynthesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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