Abstract
1. Rats were injected with 0·8 mg nicotine/kg, 0·8 mg amphetamine/kg or with saline immediately before being tested for 30 min in activity boxes.
2. During the first 3 trials the nicotine group were less active than the controls but from trial 5 onwards nicotine had a stimulant effect. The stimulant effect of the amphetamine did not alter with repeated injection.
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