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. 1972 Sep;46(1):151–156. doi: 10.1111/j.1476-5381.1972.tb06857.x

The occurrence of tolerance to a central depressant effect of nicotine

Cathleen F Morrison, Jane A Stephenson
PMCID: PMC1666121  PMID: 5084817

Abstract

1. Rats were injected with 0·8 mg nicotine/kg, 0·8 mg amphetamine/kg or with saline immediately before being tested for 30 min in activity boxes.

2. During the first 3 trials the nicotine group were less active than the controls but from trial 5 onwards nicotine had a stimulant effect. The stimulant effect of the amphetamine did not alter with repeated injection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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