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. 1972 Jun;45(2):299–310. doi: 10.1111/j.1476-5381.1972.tb08084.x

The inactivation of bradykinin in the pulmonary circulation of isolated lungs

Valerie A Alabaster, Y S Bakhle
PMCID: PMC1666127  PMID: 4625922

Abstract

1. The isolated lungs of guinea-pigs, rats and dogs, perfused with Krebs bicarbonate solution via the pulmonary artery, inactivated 95, 98 and 99% respectively of the bradykinin infused through them.

2. This inactivation process was not inhibited by 2-mercaptoethanol (1 mM) or EDTA (500 μM).

3. The inactivation was inhibited by 2:3-dimercaptopropanol (100 μM), N-ethylmaleimide (100 μM), and several of the bradykinin potentiating peptides from Bothrops jararaca, in both natural and synthetic forms.

4. The effect of these compounds, 2-mercaptoethanol, EDTA, 2:3-dimercaptopropanol, N-ethylmaleimide and Bothrops peptides on the pulmonary bradykininase activity is the same as their effect on pulmonary angiotensin I converting enzyme.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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