Abstract
The effect of pretreatment with cannabidiol (CBD; 50 mg/kg i.p.) on the distribution of radioactivity in chromatograms of ethyl acetate extracts of the brains of mice injected with tritiated Δ1-tetrahydrocannabinol (3H-Δ1-THC; 1·0 mg/kg i.v.) was determined. The pretreatment with CBD produced significant increases in the levels of radioactivity in the brain assigned to Δ1-THC and its centrally active metabolite 7-hydroxy-Δ1-THC: the changes produced were respectively 1·4 and 2·0 fold.
Pretreatment with CBD did not bring about any detectable change in the degree of 'catalepsy' produced by Δ1-THC. This negative finding may have been due to the wide limits of error that were obtained in the bioassay.
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Selected References
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- Christensen H. D., Freudenthal R. I., Gidley J. T., Rosenfeld R., Boegli G., Testino L., Brine D. R., Pitt C. G., Wall M. E. Activity of delta8- and delta9-tetrahydrocannabinol and related compounds in the mouse. Science. 1971 Apr 9;172(3979):165–167. doi: 10.1126/science.172.3979.165. [DOI] [PubMed] [Google Scholar]
- Mechoulam R. Marihuana chemistry. Science. 1970 Jun 5;168(3936):1159–1166. doi: 10.1126/science.168.3936.1159. [DOI] [PubMed] [Google Scholar]
- Mechoulam R., Shani A., Edery H., Grunfeld Y. Chemical basis of hashish activity. Science. 1970 Aug 7;169(3945):611–612. doi: 10.1126/science.169.3945.611. [DOI] [PubMed] [Google Scholar]
- Paton W. D., Pertwee R. G. Effect of cannabis and certain of its constituents on pentobarbitone sleeping time and phenazone metabolism. Br J Pharmacol. 1972 Feb;44(2):250–261. [PMC free article] [PubMed] [Google Scholar]
- Wahlqvist M., Nilsson I. M., Sandberg F., Agurell S. Binding of delta-1-tetrahydrocannabinol to human plasma proteins. Biochem Pharmacol. 1970 Sep;19(9):2579–2584. doi: 10.1016/0006-2952(70)90007-9. [DOI] [PubMed] [Google Scholar]