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. 1972 May;45(1):129–132.

Colchicine inhibits adrenal medullary secretion evoked by acetylcholine without affecting that evoked by potassium

W W Douglas, M Sorimachi
PMCID: PMC1666214  PMID: 5041460

Abstract

In perfused rabbit adrenal glands, colchicine (500 μM) inhibited the catecholamine secretion evoked by acetylcholine (20 μg/ml) but not that evoked by excess potassium (60 mM). Since both stimuli are believed to release catecholamines ultimately by the same secretory process, exocytosis, it is concluded that these inhibitory effects of colchicine exerted against acetylcholine result from an action early in the process of stimulus-secretion coupling, possibly at the level of the acetylcholine receptor, and that it is inappropriate to use such inhibitory effects to support the view that secretion proper (exocytosis) in chromaffin cells involves colchicine-sensitive elements such as microtubules.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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