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. 1975 Jan;53(1):59–66. doi: 10.1111/j.1476-5381.1975.tb07330.x

A further investigation into the energy dependence of angiotensin II-induced contractions of isolated smooth muscle preparations.

A D Crocker, K A Wilson
PMCID: PMC1666263  PMID: 1125492

Abstract

1 The energy dependence of angiotensin and acetylcholine-induced contractions of rat descending colon and uterus was investigated. 2 Differences were observed in the effect of anaerobic substrate depletion upon responses of colon and oestrous and dioestrous uterus. These were attributed to differences in the energy metabolism of the tissues and were correlated with differences in tissue levels of glycogen. 3 The preferential reduction of angiotensin responses of dioestrous uterus and descending colon when exposed to 2,4-dinitrophenol, was evidence for an energy dependent stage in the angiotensin response distinct from the contraction process itself. 4 The absence of a preferential reduction of the angiotensin response of oestrous uterus when exposed to 2,4-dinitrophenol appeared to be related to the ability of this tissue to generate ATP by anaerobic glycolysis. 5 It was concluded that the energy for the angiotensin response may be derived either anaerobically or aerobically, depending upon the tissue.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AXELSSON J., HOEGBERG S. G., TIMMS A. R. THE EFFECT OF REMOVING AND READMITTING GLUCOSE ON THE ELECTRICAL AND MECHANICAL ACTIVITY AND GLUCOSE AND GLYCOGEN CONTENT OF INTESTINAL SMOOTH MUSCLE FROM THE TAENIA COLI OF THE GUINEA PIG. Acta Physiol Scand. 1965 May-Jun;64:28–42. doi: 10.1111/j.1748-1716.1965.tb04151.x. [DOI] [PubMed] [Google Scholar]
  2. BORN G. V., BULBRING E. The effect of 2:4-dinitrophenol (DNP) on the smooth muscle of the guinea-pig's taenia coli. J Physiol. 1955 Mar 28;127(3):626–635. doi: 10.1113/jphysiol.1955.sp005283. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BORN G. V. The relation between the tension and the high-energy phosphate content of smooth muscle. J Physiol. 1956 Mar 28;131(3):704–711. doi: 10.1113/jphysiol.1956.sp005495. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bolton T. B. The depolarizing action of acetylcholine or carbachol in intestinal smooth muscle. J Physiol. 1972 Feb;220(3):647–671. doi: 10.1113/jphysiol.1972.sp009728. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. CSAPO A., GERGELY J. Energetics of uterine muscle contraction. Nature. 1950 Dec 23;166(4234):1078–1079. doi: 10.1038/1661078a0. [DOI] [PubMed] [Google Scholar]
  6. Coe J., Detar R., Bohr D. F. Substrates and vascular smooth muscle contraction. Am J Physiol. 1968 Feb;214(2):245–250. doi: 10.1152/ajplegacy.1968.214.2.245. [DOI] [PubMed] [Google Scholar]
  7. Crocker A. D., Wilson K. A. A preliminary investigation into the metabolic requirements of the contractile response of guinea-pig ileum to angiotensin. Br J Pharmacol. 1972 May;45(1):150P–151P. [PMC free article] [PubMed] [Google Scholar]
  8. Crocker A. D., Wilson K. A. A study of the metabolic requirements for the contractile action of angiotensin upon guinea-pig ileum. Br J Pharmacol. 1974 May;51(1):73–79. doi: 10.1111/j.1476-5381.1974.tb09634.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. DANIEL E. E. INTERCONNECTION BETWEEN ACTIVE TRANSPORT AND CONTRACTURE IN UTERINE TISSUES. Can J Physiol Pharmacol. 1964 Jul;42:453–495. doi: 10.1139/y64-054. [DOI] [PubMed] [Google Scholar]
  10. DAY M., VANE J. R. An analysis of the direct and indirect actions of drugs on the isolated guinea-pig ileum. Br J Pharmacol Chemother. 1963 Feb;20:150–170. doi: 10.1111/j.1476-5381.1963.tb01306.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Detar R., Bohr D. F. Adaptation to hypoxia in vascular smooth muscle. Fed Proc. 1968 Nov-Dec;27(6):1416–1419. [PubMed] [Google Scholar]
  12. Detar R., Bohr D. F. Contractile responses of isolated vascular smooth muscle during prolonged exposure to anoxia. Am J Physiol. 1972 May;222(5):1269–1277. doi: 10.1152/ajplegacy.1972.222.5.1269. [DOI] [PubMed] [Google Scholar]
  13. Detar R., Bohr D. F. Oxygen and vascular smooth muscle contraction. Am J Physiol. 1968 Feb;214(2):241–244. doi: 10.1152/ajplegacy.1968.214.2.241. [DOI] [PubMed] [Google Scholar]
  14. Dickens F., Weil-Malherbe H. Metabolism of normal and tumour tissue: The metabolism of intestinal mucous membrane. Biochem J. 1941 Jan;35(1-2):7–15. doi: 10.1042/bj0350007. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Evans C. L. Studies on the physiology of plain muscle: II. The oxygen usage of plain muscle, and its relation to tonus. J Physiol. 1923 Oct 22;58(1):22–32. doi: 10.1113/jphysiol.1923.sp002097. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. FARAH A., WEST T. C., ANGEL R. The action of sodium fluoroacetate on intestinal smooth muscle. J Pharmacol Exp Ther. 1950 Mar;98(3):234–244. [PubMed] [Google Scholar]
  17. FURCHGOTT R. F., WALES M. Effect of pH on contractile activity of rabbit intestinal smooth muscle with and without added substrates. Am J Physiol. 1951 Nov;167(2):386–398. doi: 10.1152/ajplegacy.1951.167.2.386. [DOI] [PubMed] [Google Scholar]
  18. Garry R. C. The effect of oxygen lack on surviving smooth muscle. J Physiol. 1928 Nov 9;66(3):235–248. doi: 10.1113/jphysiol.1928.sp002522. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Godfraind T., Kaba A., Polster P. Specific antagonism to the direct and indirect action of angiotensin on isolated guinea-pig ileum. Br J Pharmacol Chemother. 1966 Oct;28(1):93–104. doi: 10.1111/j.1476-5381.1966.tb01877.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Greenberg S., Wilson W. R., Long J. P. Effect of metabolic inhibitors on mesenteric arterial smooth muscle. Arch Int Pharmacodyn Ther. 1973 Dec;206(2):213–228. [PubMed] [Google Scholar]
  21. Gross L., Clark A. J. The influence of oxygen supply on the response of the isolated intestine to drugs. J Physiol. 1923 Aug 16;57(6):457–460. doi: 10.1113/jphysiol.1923.sp002084. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Hughes M. J., Coret I. A. Metabolic transients: hypoxic and oxygenated rabbit aorta with and without substrate. Am J Physiol. 1968 Aug;215(2):318–323. doi: 10.1152/ajplegacy.1968.215.2.318. [DOI] [PubMed] [Google Scholar]
  23. Kerly M. The effect of oestrone on the metabolism of rat uterus. Biochem J. 1940 Jun;34(6):814–819. doi: 10.1042/bj0340814. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Kerly M. The effect of the oestrous cycle on the metabolism of isolated rat uterus. Biochem J. 1937 Sep;31(9):1544–1552. doi: 10.1042/bj0311544. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Lo S., Russell J. C., Taylor A. W. Determination of glycogen in small tissue samples. J Appl Physiol. 1970 Feb;28(2):234–236. doi: 10.1152/jappl.1970.28.2.234. [DOI] [PubMed] [Google Scholar]
  26. Namm D. H., Zucker J. L. Biochemical alterations caused by hypoxia in the isolated rabbit aorta. Correlation with changes in arterial contractility. Circ Res. 1973 Apr;32(4):464–470. doi: 10.1161/01.res.32.4.464. [DOI] [PubMed] [Google Scholar]
  27. PATON W. D., ROTHSCHILD A. M. THE CHANGES IN RESPONSE AND IN IONIC CONTENT OF SMOOTH MUSCLE PRODUCED BY ACETYLCHOLINE ACTON AND BY CALCIUM DEFICIENCY. Br J Pharmacol Chemother. 1965 Apr;24:437–448. doi: 10.1111/j.1476-5381.1965.tb01731.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Prasad B. N. The mechanical activity of gut muscle under anaerobic conditions. J Physiol. 1935 Oct 26;85(2):249–266. doi: 10.1113/jphysiol.1935.sp003316. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. REGOLI D., VANE J. R. A SENSITIVE METHOD FOR THE ASSAY OF ANGIOTENSIN. Br J Pharmacol Chemother. 1964 Oct;23:351–359. doi: 10.1111/j.1476-5381.1964.tb01591.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. ROBERTSON P. A., RUBIN D. Stimulation of intestinal nervous elements by angiotensin. Br J Pharmacol Chemother. 1962 Aug;19:5–12. doi: 10.1111/j.1476-5381.1962.tb01423.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Rangachari P. K., Paton D. M., Daniel E. E. Aerobic and glycolytic support of sodium pumping and contraction in rat myometrium. Am J Physiol. 1972 Nov;223(5):1009–1015. doi: 10.1152/ajplegacy.1972.223.5.1009. [DOI] [PubMed] [Google Scholar]
  32. Sherratt H. S. The metabolism of the small intestine. Oxygen uptake and L-lactate production along the length of the small intestine of the rat and guinea pig. Comp Biochem Physiol. 1968 Mar;24(3):745–761. doi: 10.1016/0010-406x(68)90787-1. [DOI] [PubMed] [Google Scholar]
  33. Shibata S., Briggs A. H. Mechanical activity of vascular smooth muscle under anoxia. Am J Physiol. 1967 May;212(5):981–984. doi: 10.1152/ajplegacy.1967.212.5.981. [DOI] [PubMed] [Google Scholar]
  34. WALAAS O., WALAAS E., LOKEN F. Effect of oestradiol monobenzoate on the metabolism of rat uterine muscle. Acta Endocrinol (Copenh) 1952 Jul;10(3):201–211. doi: 10.1530/acta.0.0100201. [DOI] [PubMed] [Google Scholar]
  35. WALAAS O., WALAAS E. The content of adenosinetriphosphate and creatine phosphate in uterine muscle of rats and rabbits. Acta Physiol Scand. 1950;21(1):1–17. doi: 10.1111/j.1748-1716.1950.tb00159.x. [DOI] [PubMed] [Google Scholar]
  36. WEST T. C., CERVONI P. Influence of ovarian hormones on uterine glycogen in the rat; glycogen requirements for contractility under varying environmental conditions in vitro. Am J Physiol. 1955 Aug;182(2):287–291. doi: 10.1152/ajplegacy.1955.182.2.287. [DOI] [PubMed] [Google Scholar]
  37. WEST T. C., HADDEN G., FARAH A. Effect of anoxia on response of the isolated intestine to various drugs and enzyme inhibitors. Am J Physiol. 1951 Feb;164(2):565–572. doi: 10.1152/ajplegacy.1951.164.2.565. [DOI] [PubMed] [Google Scholar]
  38. WEST T. C., JONES D. M., LOOMIS T. A. Effect of ovarian hormones on contractile energy of rat uterus. Am J Physiol. 1953 Mar;172(3):541–546. doi: 10.1152/ajplegacy.1953.172.3.541. [DOI] [PubMed] [Google Scholar]

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