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. 1975 Jan;53(1):127–130. doi: 10.1111/j.1476-5381.1975.tb07339.x

Activation of histidine decarboxylase by H2-receptor blockade: mechanism of action.

R Häkanson, J Hedenbro, G Liedberg, J F Rehfeld, F Stadil
PMCID: PMC1666275  PMID: 236059

Abstract

1 Treatment with histamine H2-receptor antagonists, which inhibit basal acid secretion was found to activate rat stomach histidine decarboxylase. At the same time the serum gastrin concentration was greatly increased. 2 In antrectomized rats neither the enzyme activity nor the serum gastrin concentration was affected by the treatment. 3 In analogy with previous observations on other inhibitors of acid secretion we suggest that the H2-receptor antagonists stimulate gastrin release through their effect on acid secretion and that the raised serum gastrin level is responsible for the enzyme activation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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