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. 1975 May;54(1):55–60. doi: 10.1111/j.1476-5381.1975.tb07409.x

The effects of cyclic adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate and theophylline on renin secretion in the isolated perfused kidney of the rat.

W S Peart, T Quesada, I Tenyi
PMCID: PMC1666401  PMID: 166719

Abstract

1. The influence of cyclic adenosine 3',5'-monophosphate (cyclic AMP), cylic guanosine 3',5'-monophosphate (cyclic GMP) and theophylline on renin secretion was examined in the isolated kidney of the rat perfused with Krebs dextran solution. 2. Neither cyclic AMP (10(-6) to 10(-4) M) nor dibytyryl cyclic AMP (10(-5) M) produced an increase in renin secretion. 3. Cyclic GMP and 8 Br-cyclic GMP caused a small rise in renin secretion in some experiments but this effect was independent of the dose and its physiological significance is uncertain. 4. Theophylline (10(-6) to 10(14) M) caused a significant elevation in renin secretion which was not blocked by (+)-propranolol. Theophylline with cyclic AMP or cyclic GMP did not produce an amplified effect. 5. Despite previous suggestions that cyclic AMP stimulated renin secretion, this could not be confirmed in the present preparation. Since there is no evidence that cyclic AMP or cyclic GMP (or their derivatives, dibutyryl cyclic AMP and 8 Br-cyclic GMP) enter the cells, it will be necessary to study their activity in isolated juxtaglomerular cells to define a possible role.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ASHMAN D. F., LIPTON R., MELICOW M. M., PRICE T. D. Isolation of adenosine 3', 5'-monophosphate and guanosine 3', 5'-monophosphate from rat urine. Biochem Biophys Res Commun. 1963 May 22;11:330–334. doi: 10.1016/0006-291x(63)90566-7. [DOI] [PubMed] [Google Scholar]
  2. Assaykeen T. A., Clayton P. L., Goldfien A., Ganong W. F. The effect of alpha- and beta-adrenergic blocking agents on the renin response to hypoglycemia and epinephrine in dogs. Endocrinology. 1970 Dec;87(6):1318–1322. doi: 10.1210/endo-87-6-1318. [DOI] [PubMed] [Google Scholar]
  3. BUTCHER R. W., SUTHERLAND E. W. Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine. J Biol Chem. 1962 Apr;237:1244–1250. [PubMed] [Google Scholar]
  4. Beck N. P., Reed S. W., Murdaugh H. V., Davis B. B. Effects of catecholamines and their interaction with other hormones on cyclic 3',5'-adenosine monophosphate of the kidney. J Clin Invest. 1972 Apr;51(4):939–944. doi: 10.1172/JCI106888. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Blinks J. R., Olson C. B., Jewell B. R., Bravený P. Influence of caffeine and other methylxanthines on mechanical properties of isolated mammalian heart muscle. Evidence for a dual mechanism of action. Circ Res. 1972 Apr;30(4):367–392. doi: 10.1161/01.res.30.4.367. [DOI] [PubMed] [Google Scholar]
  6. Boyd G. W., Fitz A. E., Adamson A. R., Peart W. S. Radioimmunoassay determination of plasma-renin activity. Lancet. 1969 Feb 1;1(7588):213–218. doi: 10.1016/s0140-6736(69)91237-9. [DOI] [PubMed] [Google Scholar]
  7. Eichhorn J. H., Salzman E. W., Silen W. Cyclic GMP response in vivo to cholinergic stimulation of gastric mucosa. Nature. 1974 Mar 15;248(445):238–239. doi: 10.1038/248238a0. [DOI] [PubMed] [Google Scholar]
  8. Estensen R. D., Hill H. R., Quie P. G., Gogan N., Goldberg N. D. Cyclic GMP and cell movement. Nature. 1973 Oct 26;245(5426):458–460. doi: 10.1038/245458a0. [DOI] [PubMed] [Google Scholar]
  9. Ishikawa E., Ishikawa S., Davis J. W., Sutherland E. W. Determination of guanosine 3',5'-monophosphate in tissues and of guanyl cyclase in rat intestine. J Biol Chem. 1969 Dec 10;244(23):6371–6376. [PubMed] [Google Scholar]
  10. Johns E. J., Singer B. Effect of propranolol and theophylline on renin release caused by furosemide in the cat. Eur J Pharmacol. 1973 Jul;23(1):67–73. doi: 10.1016/0014-2999(73)90245-8. [DOI] [PubMed] [Google Scholar]
  11. Johnson J. A., Davis J. O., Witty R. T. Effects of catecholamines and renal nerve stimulation on renin release in the nonfiltering kidney. Circ Res. 1971 Dec;29(6):646–653. doi: 10.1161/01.res.29.6.646. [DOI] [PubMed] [Google Scholar]
  12. Kolata G. B. Cyclic GMP: Cellular Regulatory Agent? Science. 1973 Oct 12;182(4108):149–151. doi: 10.1126/science.182.4108.149. [DOI] [PubMed] [Google Scholar]
  13. Michelakis A. M., Caudle J., Liddle G. W. In vitro stimulation of renin production by epinephrine, norepinephrine, and cyclic AMP. Proc Soc Exp Biol Med. 1969 Mar;130(3):748–753. doi: 10.3181/00379727-130-33647. [DOI] [PubMed] [Google Scholar]
  14. Murad F., Vaughan M. Effect of glucagon on rat heart adenyl cyclase. Biochem Pharmacol. 1969 May;18(5):1053–1059. doi: 10.1016/0006-2952(69)90109-9. [DOI] [PubMed] [Google Scholar]
  15. Reid I. A., Stockigt J. R., Goldfien A., Ganong W. F. Stimulation of renin secretion in dogs by theophylline. Eur J Pharmacol. 1972 Mar;17(3):325–332. doi: 10.1016/0014-2999(72)90112-4. [DOI] [PubMed] [Google Scholar]
  16. Ryan W. L., Durick M. A. Adenosine 3',5'-monophosphate and N 6 -2'-O-dibutyryl-adenosine 3',5'-monophosphate transport in cells. Science. 1972 Sep 15;177(4053):1002–1003. doi: 10.1126/science.177.4053.1002. [DOI] [PubMed] [Google Scholar]
  17. Sutherland E. W., Robison G. A. The role of cyclic-3',5'-AMP in responses to catecholamines and other hormones. Pharmacol Rev. 1966 Mar;18(1):145–161. [PubMed] [Google Scholar]
  18. Sutherland E. W. Studies on the mechanism of hormone action. Science. 1972 Aug 4;177(4047):401–408. doi: 10.1126/science.177.4047.401. [DOI] [PubMed] [Google Scholar]
  19. Tagawa H., Vander A. J. Effects of adenosine compounds on renal function and renin secretion in dogs. Circ Res. 1970 Mar;26(3):327–338. doi: 10.1161/01.res.26.3.327. [DOI] [PubMed] [Google Scholar]
  20. Ueda H., Yasuda H., Takabatake Y., Iizuka M., Iizuka T. Observations on the mechanism of renin release by catecholamines. Circ Res. 1970 Oct;27(Suppl):195+–195+. [PubMed] [Google Scholar]
  21. Van Dongen R., Peart W. S. Calcium dependence of the inhibitory effect of angiotensin on renin secretion in the isolated perfused kidney of the rat. Br J Pharmacol. 1974 Jan;50(1):125–129. doi: 10.1111/j.1476-5381.1974.tb09599.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Vander A. J. Effect of catecholamines and the renal nerves on renin secretion in anesthetized dogs. Am J Physiol. 1965 Sep;209(3):659–662. doi: 10.1152/ajplegacy.1965.209.3.659. [DOI] [PubMed] [Google Scholar]
  23. Vandongen R., Peart W. S., Boyd G. W. Andrenergic stimulation of renin secretion in the isolated perfused rat kidney. Circ Res. 1973 Feb;32(2):290–296. doi: 10.1161/01.res.32.2.290. [DOI] [PubMed] [Google Scholar]
  24. Wathen R. L., Kingsbury W. S., Stouder D. A., Schneider E. G., Rostorfer H. H. Effects of infusion of catecholamines and angiotensin II on renin release in anesthetized dogs. Am J Physiol. 1965 Nov;209(5):1012–1024. doi: 10.1152/ajplegacy.1965.209.5.1012. [DOI] [PubMed] [Google Scholar]
  25. Winer N., Chokshi D. S., Walkenhorst W. G. Effects of cyclic AMP, sympathomimetic amines, and adrenergic receptor antagonists on renin secretion. Circ Res. 1971 Sep;29(3):239–248. doi: 10.1161/01.res.29.3.239. [DOI] [PubMed] [Google Scholar]
  26. Winer N., Chokshi D. S., Yoon M. S., Freedman A. D. Adrenergic receptor mediation of renin secretion. J Clin Endocrinol Metab. 1969 Sep;29(9):1168–1175. doi: 10.1210/jcem-29-9-1168. [DOI] [PubMed] [Google Scholar]
  27. Wooten G. F., Thoa N. B., Kopin I. J., Axelrod J. Enhanced release of dopamine -hydroxylase and norepinephrine from sympathetic nerves by dibutyryl cyclic adenosine 3', 5'-monophosphate and theophylline. Mol Pharmacol. 1973 Mar;9(2):178–183. [PubMed] [Google Scholar]
  28. Yamamoto K., Okahara T., Abe Y., Ueda J., Kishimoto T. Effects of cyclic AMP and dibutyryl cyclic AMP on renin release in vivo and in vitro. Jpn Circ J. 1973 Oct;37(10):1271–1276. doi: 10.1253/jcj.37.1271. [DOI] [PubMed] [Google Scholar]

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