Skip to main content
NCBI home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1975 Mar;53(3):333–340. doi: 10.1111/j.1476-5381.1975.tb07368.x

Lack of cardiac or bronchodilator tachyphylaxis to isoprenaline in the dog.

H Minatoya, B A Spilker
PMCID: PMC1666415  PMID: 1137727

Abstract

1. Tachyphylaxis to heart rate and bronchodilator effects of (plus or minus)-isoprenaline was studied in anaesthetized open-chest dogs by 5 procedures. 2. Heart rate responses to a series of intravenous injections of isoprenaline were essentially unchanged before and after a 15 min infusion of isoprenaline (at 3 doses). 3. Heart rate and bronchodilator responses in the same animal to an intravenous injection of isoprenaline were not significantly different before and after a 30 min infusion of isoprenaline (at 2 doses). 4. Heart rate responses were relatively constant to an isoprenaline injection given every 30 min during a 4 h infusion of isoprenaline (at 3 doses), but the magnitude of the response was smallest for the largest infusion dose (highest background heart rate) and greatest for the smallest infusion dose (lowest background heart rate). 5. Heart rate and bronchodilator responses in the same animal to isoprenaline were relatively constant during a 5 h infusion of isoprenaline (at 2 doses). 6. Bronchodilator responses to intratracheally administered isoprenaline aerosol were essentially unchanged during a 4-5 h period using various doses and procedures. 7. Tachyphylaxis to the heart rate of bronchodilator effects of isoprenaline was not observed. The present data give no support to the hypothesis that tachyphylaxis to isoprenaline aerosols is an important mechanism in asthma mortality.

Full text

PDF
333

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atkinson J. M., Rand M. J. Mutal suppression of cardiovascular effects of some beta-adrenoreceptor agonists in the cat. J Pharm Pharmacol. 1968 Dec;20(12):916–922. doi: 10.1111/j.2042-7158.1968.tb09674.x. [DOI] [PubMed] [Google Scholar]
  2. COOKSON D. U., REED C. E. A COMPARISON OF THE EFFECTS OF ISOPROTERENOL IN THE NORMAL AND ASTHMATIC SUBJECT. A PRELIMINARY REPORT. Am Rev Respir Dis. 1963 Nov;88:636–643. doi: 10.1164/arrd.1963.88.5.636. [DOI] [PubMed] [Google Scholar]
  3. Conolly M. E., Davies D. S., Dollery C. T., George C. F. Resistance to -adrenoceptor stimulants (a possible explanation for the rise in ashtma deaths). Br J Pharmacol. 1971 Oct;43(2):389–402. [PMC free article] [PubMed] [Google Scholar]
  4. Daly M. J., Farmer J. B., Levy G. P. Comparison of the bronchodilator and cardiovascular actions of salbutamol, isoprenaline and orciprenaline in guinea-pigs and dogs. Br J Pharmacol. 1971 Nov;43(3):624–638. doi: 10.1111/j.1476-5381.1971.tb07192.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Ekue J. M., Shanks R. G., Zaidi S. A. Comparison of the effects of isoprenaline, orciprenaline, salbutamol and isoetharine on the cardiovascular system of anaesthetized dogs. Br J Pharmacol. 1971 Sep;43(1):23–31. doi: 10.1111/j.1476-5381.1971.tb07153.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Fleisch J. H., Titus E. The prevention of isoproterenol desensitization and isoproterenol reversal. J Pharmacol Exp Ther. 1972 Jun;181(3):425–433. [PubMed] [Google Scholar]
  7. Freedman B. J., Hill G. B. Comparative study of duration of action and cardiovascular effects of bronchodilator aerosols. Thorax. 1971 Jan;26(1):46–50. doi: 10.1136/thx.26.1.46. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gandevia B. Pressurized sympathomimetic aerosols and their lack of relationship to asthma mortality in Australia. Med J Aust. 1973 Feb 10;1(6):273–277. doi: 10.5694/j.1326-5377.1973.tb119742.x. [DOI] [PubMed] [Google Scholar]
  9. Hambleton G., Shinebourne E. A. Evaluation of the effects of isoprenaline and salbutamol aerosols on airways obstruction and pulse rates of children with asthma. Arch Dis Child. 1970 Dec;45(244):766–768. doi: 10.1136/adc.45.244.766. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Harris M. C. Are bronchodilator aerosol inhalations responsible for an increase in asthma mortality? Ann Allergy. 1971 May;29(5):250–256. [PubMed] [Google Scholar]
  11. Harris M. C. Isoproterenol in chronic asthmatic patients who do not require hospital treatment. Ann Allergy. 1972 Jun;30(6):315–320. [PubMed] [Google Scholar]
  12. Herxheimer H. Asthma deaths. Br Med J. 1972 Dec 30;4(5843):795–795. doi: 10.1136/bmj.4.5843.795-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Herxheimer H. Asthma mortality and pressurised aerosols. Lancet. 1969 Sep 20;2(7621):642–643. doi: 10.1016/s0140-6736(69)90350-x. [DOI] [PubMed] [Google Scholar]
  14. Keighley J. F. Iatrogenic asthma associated with adrenergic aerosols. Ann Intern Med. 1966 Nov;65(5):985–995. doi: 10.7326/0003-4819-65-5-985. [DOI] [PubMed] [Google Scholar]
  15. Kingsley P. J., Littlejohns D. W., Prichard B. N. Isoprenaline-induced tachycardia in man. Br J Pharmacol. 1972 Nov;46(3):539P–540P. [PMC free article] [PubMed] [Google Scholar]
  16. McCulloch M. W., Pun L. Q., Rand M. J. Deaths from asthma. Br Med J. 1968 May 18;2(5602):429–429. doi: 10.1136/bmj.2.5602.429-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. McDevitt D. G., Shanks R. G., Swanton J. G. Further observations on the cardiotoxicity of isoprenaline during hypoxia. Br J Pharmacol. 1974 Mar;50(3):335–344. doi: 10.1111/j.1476-5381.1974.tb09608.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Palmer K. N., Diament M. L. Effect of aerosol isoprenaline on blood-gas tensions in severe bronchial asthma. Lancet. 1967 Dec 9;2(7528):1232–1233. doi: 10.1016/s0140-6736(67)90567-3. [DOI] [PubMed] [Google Scholar]
  19. Paterson J. W., Conolly M. E., Davies D. S., Dollery C. T. Isoprenaline resistance and the use of pressurised aerosols in asthma. Lancet. 1968 Aug 24;2(7565):426–429. doi: 10.1016/s0140-6736(68)90467-4. [DOI] [PubMed] [Google Scholar]
  20. Pierson R. N., Jr, Grieco M. H. Isoproterenol aerosol in normal and asthmatic subjects. Time relationship of pulmonary and hemodynamic responses. Am Rev Respir Dis. 1969 Oct;100(4):533–541. doi: 10.1164/arrd.1969.100.4.533. [DOI] [PubMed] [Google Scholar]
  21. Pun L. Q., McCulloch M. W., Rand M. J. Bronchodilator effects of sympathomimetic amines given singly and in combination. Eur J Pharmacol. 1971 Apr;14(2):140–149. doi: 10.1016/0014-2999(71)90207-x. [DOI] [PubMed] [Google Scholar]
  22. Riding W. D., Chatterjee S. S., Bernstein A., Dinda P. A comparison of the cardiorespiratory effects of salbutamol and isoproterenol-phenylephrine aerosols in asthma. Am Rev Respir Dis. 1971 Nov;104(5):688–693. doi: 10.1164/arrd.1971.104.5.688. [DOI] [PubMed] [Google Scholar]
  23. Sobol B. J., Emirgil C., Wadhwani B., Goyal P. Simple ventilatory tests for assessing response to bronchodilator in chronic obstructive pulmonary disease. Anesth Analg. 1972 Jan-Feb;51(1):21–26. [PubMed] [Google Scholar]
  24. Spilker B. Letter: Increase in asthma mortality. Br Med J. 1973 Oct 20;4(5885):171–172. doi: 10.1136/bmj.4.5885.171-c. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Stolley P. D. Asthma mortality. Why the United States was spared an epidemic of deaths due to asthma. Am Rev Respir Dis. 1972 Jun;105(6):883–890. doi: 10.1164/arrd.1972.105.6.883. [DOI] [PubMed] [Google Scholar]
  26. Van Metre T. E., Jr Adverse effects of inhalation of excessive amounts of nebulized isoproterenol in status asthmaticus. J Allergy. 1969 Feb;43(2):101–113. doi: 10.1016/0021-8707(69)90130-0. [DOI] [PubMed] [Google Scholar]
  27. Waddell J. A., Emerson P. A., Gunstone R. F. Hypoxia in bronchial asthma. Br Med J. 1967 May 13;2(5549):402–404. doi: 10.1136/bmj.2.5549.402. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES