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. 1975 Mar;53(3):341–347. doi: 10.1111/j.1476-5381.1975.tb07369.x

An investigation of the tachycardia produced by intracerebro-ventricular injections of isoprenaline in mice.

D T Burden, M W Parkes
PMCID: PMC1666444  PMID: 1137728

Abstract

1. Isoprenaline, 3.5-20 ng, injected intracerebroventricularly in atropinized mice under pentobarbitone anaesthesia produced a dose-dependent tachycardia. 2. Pretreatment with either reserpine or pempidine blocked nervously-mediated tachycardia as shown by marked reduction of that due to stimulation of the spinal outflow in pithed mice. After pretreatment with these drugs, intracerebroventricular isoprenaline caused tachycardia of a similar degree and time course to that in mice not so pretreated. 3. Pretreatment with either reserpine or pempidine caused supersensitivity to the tachycardia due to intravenous isoprenaline. 4. When allowance was made for this supersensitivity in the effect of intracerebroventricular isoprenaline in pretreated mice, a small dose-dependent residual effect remained that could be attributed to leakage of isoprenaline into the peripheral circulation. 5. This was confirmed by the appearance of a late-developing tachycardia on intracerebroventricular injection of isoprenaline in spinal mice. 6. It is therefore concluded that the tachycardia caused by intracerebroventricular isoprenaline in mice is, at least initially, of central origin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barrett A. M., Carter J. Comparative chronotropic activity of beta-adrenoceptive antagonists. Br J Pharmacol. 1970 Nov;40(3):373–381. doi: 10.1111/j.1476-5381.1970.tb10619.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bhargava K. P., Mishra N., Tangri K. K. An analysis of central adrenoceptors for control of cardiovascular function. Br J Pharmacol. 1972 Aug;45(4):596–602. doi: 10.1111/j.1476-5381.1972.tb08117.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Brittain R. T. The intracerebral effects of noradrenaline and its modification by drugs in the mouse. J Pharm Pharmacol. 1966 Sep;18(9):621–623. doi: 10.1111/j.2042-7158.1966.tb07944.x. [DOI] [PubMed] [Google Scholar]
  4. Cowell P., Davey M. J. The reversal of the central effects of noradrenaline by antidepressant drugs in mice. Br J Pharmacol. 1968 Sep;34(1):159–168. doi: 10.1111/j.1476-5381.1968.tb07959.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Day M. D., Roach A. G. Adrenoceptors in the central nervous system concerned with cardiovascular control. J Pharm Pharmacol. 1972 Dec;24(Suppl):148P–148P. [PubMed] [Google Scholar]
  6. Gagnon D. J., Melville K. I. Centrally mediated cardiovascular responses to isoprenaline. Int J Neuropharmacol. 1967 Jul;6(4):245–251. doi: 10.1016/0028-3908(67)90012-3. [DOI] [PubMed] [Google Scholar]
  7. Gillespie J. S., Muir T. C. A method of stimulating the complete sympathetic outflow from the spinal cord to blood vessels in the pithed rat. Br J Pharmacol Chemother. 1967 May;30(1):78–87. doi: 10.1111/j.1476-5381.1967.tb02114.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. HALEY T. J., MCCORMICK W. G. Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse. Br J Pharmacol Chemother. 1957 Mar;12(1):12–15. doi: 10.1111/j.1476-5381.1957.tb01354.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. KANEKO Y., MCCUBBIN J. W., PAGE I. H. Mechanism by which serotonin, norepinephrine and reserpine cause central vasomotor inhibition. Circ Res. 1960 Nov;8:1228–1234. doi: 10.1161/01.res.8.6.1228. [DOI] [PubMed] [Google Scholar]
  10. MCCUBBIN J. W., KANEKO Y., PAGE I. H. Ability of serotonin and norepinephrine to mimic the central effects of reserpine on vasomotor activity. Circ Res. 1960 Jul;8:849–858. doi: 10.1161/01.res.8.4.849. [DOI] [PubMed] [Google Scholar]
  11. SHARE N. N., MELVILLE K. I. INTRAVENTRICULAR INJECTIONS OF PICROTOXIN FOLLOWING CENTRAL ADRENERGIC BLOCKADE WITH PHENOXYBENZAMINE AND DICHLOROISOPROTERENOL. Int J Neuropharmacol. 1965 May;4:149–156. doi: 10.1016/0028-3908(65)90004-3. [DOI] [PubMed] [Google Scholar]
  12. SHARE N. N., MELVILLE K. I. INVOLVEMENT OF BRAIN STEM NOREPINEPHRINE IN PICROTOXIN AND TYRAMINE-INDUCED CENTRAL SYMPATHETIC STIMULATION. Arch Int Pharmacodyn Ther. 1965 Feb;153:267–282. [PubMed] [Google Scholar]
  13. Shaw G. G. Some shortcomings of direct intraventricular injection in mice. Br J Pharmacol. 1974 Apr;50(4):603–605. doi: 10.1111/j.1476-5381.1974.tb08596.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

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