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. 1975 Jul;54(3):389–396. doi: 10.1111/j.1476-5381.1975.tb07580.x

Rapid effects of environmental disturbance on rat plasma unesterified fatty acid and tryptophan concentrations and their prevention by antilopolytic drugs.

G Curzon, P J Knott
PMCID: PMC1666472  PMID: 1164595

Abstract

1 Changes of plasma unesterified fatty acid (UFA) and tryptophan concentration in group-housed rats following removal of their cage-mates and the effects of antilipolytic drugs on these changes were investigated. 2 Removal of group-housed 24 h fasted rats but not fed rats from cages resulted in increased plasma UFA concentration in the remaining rats which was associated with significant increases of the proportion of free tryptophan but significant falls of total tryptophan concentration. These rapid changes were not associated with brain tryptophan changes. Plasma tyrosine concentration was unaffected. 3 The fall of plasma tryptophan did not appear to be due to passage into red cells as erythrocyte tryptophan concentration remained unchanged. 4 Plasma UFA concentrations correlated positively and significantly with corticosterone concentrations which were also increased following removal of cage-mates. 5 Plasma UFA increases and tryptophan changes in the fasting rats were both prevented by nicotinic acid or propranolol. Corticosterone concentration was increased by nicotinic acid but unaffected by propranolol. 6 The possible importance of these rapid changes of plasma tryptophan and of their prevention by antilipolytic drugs is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARRETT A. M. ADVENTITIOUS FACTORS AFFECTING THE CONCENTRATON OF FREE FATTY ACIDS IN THE PLASMA OF RATS. Br J Pharmacol Chemother. 1964 Jun;22:577–584. doi: 10.1111/j.1476-5381.1964.tb01711.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brodie B. B., Krishna G., Hynie S. On the role of adenyl cyclase in the regulation of lipolysis in fasting. Biochem Pharmacol. 1969 May;18(5):1129–1134. doi: 10.1016/0006-2952(69)90116-6. [DOI] [PubMed] [Google Scholar]
  3. Court J. M., Dunlop M. E., Leonard R. F. High-frequency oscillation of blood free fatty acid levels in man. J Appl Physiol. 1971 Sep;31(3):345–347. doi: 10.1152/jappl.1971.31.3.345. [DOI] [PubMed] [Google Scholar]
  4. Curzon G., Friedel J., Knott P. J. The effect of fatty acids on the binding of tryptophan to plasma protein. Nature. 1973 Mar 16;242(5394):198–200. doi: 10.1038/242198a0. [DOI] [PubMed] [Google Scholar]
  5. Curzon G., Joseph M. H., Knott P. J. Effects of immobilization and food deprivation on rat brain tryptophan metabolism. J Neurochem. 1972 Aug;19(8):1967–1974. doi: 10.1111/j.1471-4159.1972.tb01486.x. [DOI] [PubMed] [Google Scholar]
  6. Curzon G., Kantamaneni B. D., Fernando J. C., Woods M. S., Cavanagh J. B. Effects of chronic porto-caval anastomosis on brain tryptophan, tyrosine and 5-hydroxytryptamine. J Neurochem. 1975 May;24(5):1065–1070. doi: 10.1111/j.1471-4159.1975.tb03678.x. [DOI] [PubMed] [Google Scholar]
  7. Curzon G., Kantamaneni B. D., Winch J., Rojas-Bueno A., Murray-Lyon I. M., Williams R. Plasma and brain tryptophan changes in experimental acute hepatic failure. J Neurochem. 1973 Jul;21(1):137–145. doi: 10.1111/j.1471-4159.1973.tb04233.x. [DOI] [PubMed] [Google Scholar]
  8. Curzon G., Knott P. J. Effects on plasma and brain tryptophan in the rat of drugs and hormones that influence the concentration of unesterified fatty acid in the plasma. Br J Pharmacol. 1974 Feb;50(2):197–204. doi: 10.1111/j.1476-5381.1974.tb08562.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Denckla W. D., Dewey H. K. The determination of tryptophan in plasma, liver, and urine. J Lab Clin Med. 1967 Jan;69(1):160–169. [PubMed] [Google Scholar]
  10. Fernando J. C., Joseph M. H., Curzon G. Letter: Tryptophan plus a pyrrolase inhibitor for depression? Lancet. 1975 Jan 18;1(7899):171–171. doi: 10.1016/s0140-6736(75)91478-6. [DOI] [PubMed] [Google Scholar]
  11. Fuller R. W., Roush B. W. Binding of tryptophan to plasma proteins in several species. Comp Biochem Physiol B. 1973 Oct 15;46(2):273–276. doi: 10.1016/0305-0491(73)90318-0. [DOI] [PubMed] [Google Scholar]
  12. Knott P. J., Curzon G. Free tryptophan in plasma and brain tryptophan metabolism. Nature. 1972 Oct 20;239(5373):452–453. doi: 10.1038/239452a0. [DOI] [PubMed] [Google Scholar]
  13. Knott P. J., Curzon G. Tryptophan and tyrosine disposition and brain tryptophan metabolism in acute carbon tetrachloride poisoning. Biochem Pharmacol. 1975 May 1;24(9):963–966. doi: 10.1016/0006-2952(75)90428-1. [DOI] [PubMed] [Google Scholar]
  14. Laurell S., Tibbling G. Colorimetric micro-determination of free fatty acids in plasma. Clin Chim Acta. 1967 Apr;16(1):57–62. doi: 10.1016/0009-8981(67)90269-0. [DOI] [PubMed] [Google Scholar]
  15. MATTINGLY D. A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. J Clin Pathol. 1962 Jul;15:374–379. doi: 10.1136/jcp.15.4.374. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. McMENAMY R. H., LUND C. C., ONCLEY J. L. Unbound amino acid concentrations in human blood plasmas. J Clin Invest. 1957 Dec;36(12):1672–1679. doi: 10.1172/JCI103568. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. McMENAMY R. H., ONCLEY J. L. The specific binding of L-tryptophan to serum albumin. J Biol Chem. 1958 Dec;233(6):1436–1447. [PubMed] [Google Scholar]
  18. Nimmo I. A., Kirby B. J., Lassers B. W. Rapid oscillations in blood glucose and plasma free fatty acid concentrations in man. J Appl Physiol. 1973 Apr;34(4):448–451. doi: 10.1152/jappl.1973.34.4.448. [DOI] [PubMed] [Google Scholar]
  19. Taggart P., Carruthers M. Endogenous hyperlipidaemia induced by emotional stress of racing driving. Lancet. 1971 Feb 20;1(7695):363–366. doi: 10.1016/s0140-6736(71)92207-0. [DOI] [PubMed] [Google Scholar]
  20. Yorkston N. J., Zaki S. A., Malik M. K., Morrison R. C., Havard C. W. Propranolol in the control of schizophrenic symptoms. Br Med J. 1974 Dec 14;4(5945):633–635. doi: 10.1136/bmj.4.5945.633. [DOI] [PMC free article] [PubMed] [Google Scholar]

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