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British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1975 Jul;54(3):400–402. doi: 10.1111/j.1476-5381.1975.tb07582.x

Depolarizing effects of the ionophores X-537A and A23187 and their relevance to secretion.

D E Cohrane, W W Douglas
PMCID: PMC1666484  PMID: 1100156

Abstract

The ionophore X-537A depolarized frog skeletal muscle fibres about 10 mV in 10 min and a further 30 mV or so over the next 50 minutes. With A23187, depolarization was relatively feeble and delayed in onset but was hastened when calcium was removed from the bathing medium. The results support conjecture that some functional responses to these ionophores are attributable, in part, to depolarization.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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