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. 1972 Nov;46(3):458–472. doi: 10.1111/j.1476-5381.1972.tb08143.x

Metabolism of isoprenaline in dog and man

M E Conolly, D S Davies, C T Dollery, C D Morgan, J W Paterson, M Sandler
PMCID: PMC1666503  PMID: 4656607

Abstract

1. The metabolism of isoprenaline has been studied in man and dog following intravenous and oral or intra-duodenal administration.

2. Intravenous isoprenaline was excreted largely unchanged in urine in both species. Only one-third of the radioactivity in urine was in the form of the O-methyl metabolite.

3. After oral doses in man or intraduodenal doses in dogs, plasma radioactivity was almost entirely as conjugated isoprenaline and this metabolite accounted for more than 80% of radioactivity in urine.

4. Catechol-O-methyl transferase may be less important than Uptake2 in limiting the pharmacological action of isoprenaline.

5. Pharmacological response (heart-rate increase) was related to plasma concentration of isoprenaline only after rapid intravenous injections. In dogs, following prolonged infusion or intraduodenal doses, heart rate returned to base-line values when plasma concentrations of isoprenaline were high.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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