Skip to main content
NCBI home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1975 Jun;54(2):197–204. doi: 10.1111/j.1476-5381.1975.tb06929.x

The effects of prostaglandins on guinea-pig isolated intestine and their possible contribution to muscle activity and tone

A Bennett, KG Eley, Helen L Stockley
PMCID: PMC1666613  PMID: 1148509

Abstract

1 Prostaglandins F1α and F2α caused contraction of the longitudinal muscle of both guinea-pig isolated ileum and colon, apparently by acting directly on the muscle and on cholinergic nerves. They had little effect on ileal circular muscle.

2 Prostaglandins E1 and E2 caused contraction of the longitudinal muscle of guinea-pig isolated colon, apparently by acting directly on the muscle and on excitatory nerves which are non-cholinergic. Prostaglandin E1 seems more effective than E2 in stimulating these nerves.

3 It seems likely that prostaglandin release in vitro maintains the tone of the longitudinal muscle of guinea-pig colon, whereas release of a prostaglandin E compound inhibits circular muscle tone.

Full text

PDF
197

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BERGSTROM S., ELIASSON R., von EULER U., SJOVALL J. Some biological effects of two crystalline prostaglandin factors. Acta Physiol Scand. 1959 Mar 31;45:133–144. doi: 10.1111/j.1748-1716.1959.tb01685.x. [DOI] [PubMed] [Google Scholar]
  2. Bennett A., Eley K. G., Scholes G. B. Effects of prostaglandins E1 and E2 on human, guinea-pig and rat isolated small intestine. Br J Pharmacol. 1968 Nov;34(3):630–638. doi: 10.1111/j.1476-5381.1968.tb08492.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bennett A., Fleshler B. Prostaglandins and the gastrointestinal tract. Gastroenterology. 1970 Nov;59(5):790–800. [PubMed] [Google Scholar]
  4. Bennett A., Posner J. Studies on prostaglandin antagonists. Br J Pharmacol. 1971 Aug;42(4):584–594. doi: 10.1111/j.1476-5381.1971.tb07142.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Botting J. H., Salzmann R. The effect of indomethacin on the release of prostaglandin E2 and acetylcholine from guinea-pig isolated ileum at rest and during field stimulation. Br J Pharmacol. 1974 Jan;50(1):119–124. doi: 10.1111/j.1476-5381.1974.tb09598.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Davison P., Ramwell P. W., Willis A. L. Inhibition of intestinal tone and prostaglandin synthesis by 5,8,11,14 tetraynoic acid. Br J Pharmacol. 1972 Nov;46(3):547P–548P. [PMC free article] [PubMed] [Google Scholar]
  7. Ehrenpreis S., Greenberg J., Belman S. Prostaglandins reverse inhibition of electrically-induced contractions of guinea pig ileum by morphine, indomethacin and acetylsalicylic acid. Nat New Biol. 1973 Oct 31;245(148):280–282. doi: 10.1038/newbio245280a0. [DOI] [PubMed] [Google Scholar]
  8. Kadlec O., Masek K., Seferna I. A modulating role of prostaglandins in contractions of the guinea-pig ileum. Br J Pharmacol. 1974 Aug;51(4):565–570. doi: 10.1111/j.1476-5381.1974.tb09675.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Karim S. M. Identification of prostaglandins in human amniotic fluid. J Obstet Gynaecol Br Commonw. 1966 Dec;73(6):903–908. doi: 10.1111/j.1471-0528.1966.tb06112.x. [DOI] [PubMed] [Google Scholar]
  10. Weeks J. R., Schultz J. R., Brown W. E. Evaluation of smooth muscle bioassays for prostaglandins E 1 and F 1 alpha. J Appl Physiol. 1968 Dec;25(6):783–785. doi: 10.1152/jappl.1968.25.6.783. [DOI] [PubMed] [Google Scholar]
  11. Wennmalm A., Hedqvist P. Inhibition by prostaglandin E1 of parasympathetic neurotransmission in the rabbit hheart. Life Sci I. 1971 Apr 15;10(8):465–470. [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES