Skip to main content
PMC home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1975 Aug;54(4):453–462. doi: 10.1111/j.1476-5381.1975.tb07591.x

Cardiovascular depressant effects of neomycin and gentamicin in rhesus monkeys.

H R Adams
PMCID: PMC1666674  PMID: 809079

Abstract

1. The acute cardiovascular effects of neomycin and gentamicin, representative aminoglycoside antibiotics, were examined in surgically-prepared anaesthetized rhesus monkeys. 2. Intravenous administration of 14, 28, and 56 mg/kg of neomycin consistently induced a dose-dependent depression of systemic blood pressure, cardiac output, left ventricular contractile force, maximum dF/dt of left ventricular contraction, and heart rate. Neomycin produced similar cardiovascular depressant effects when heart rate was maintained constant by electrical pacing. 3. Maximum depression of haemodynamic values usually occurred within 2 to 5 min after injection of neomycin; values then gradually returned to control levels within 20 to 30 (14 mg/kg) or 60 to 80 (56 mg/kg) minutes. 4. Injection of CaCl2 (1.35 mEq Ca2+/kg, i.v.) during the peak depressant effect of neomycin produced a rapid and maintained restoration of cardiovascular function to control levels; conversely, noradrenaline (2 mug, i.v.) of isoprenaline (0.5 mug, i.v.) produced only transient reversal of the neomycin effects. 5. Similar evidence of cardiovascular dysfunction was observed with gentamicin. 6. These findings demonstrate the direct cardiovascular depressant effects of aminoglycoside natibiotics in a higher primate species, and suggest that this adverse response is related to an alteration of calcium ion function.

Full text

PDF
453

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adams H. R. Direct myocardial depressant effects of gentamicin. Eur J Pharmacol. 1975 Feb;30(2):272–279. doi: 10.1016/0014-2999(75)90110-7. [DOI] [PubMed] [Google Scholar]
  2. Adams H. R., Goodman F. R. Differential inhibitory effect of neomycin on contractile responses of various canine arteries. J Pharmacol Exp Ther. 1975 May;193(2):393–402. [PubMed] [Google Scholar]
  3. Adams H. R., Goodman F. R., Weiss G. B. Alteration of contractile function and calcium ion movements in vascular smooth muscle by gentamicin and other aminoglycoside antibiotics. Antimicrob Agents Chemother. 1974 Jun;5(6):640–646. doi: 10.1128/aac.5.6.640. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cohen L. S., Wechsler A. S., Mitchell J. H., Glick G. Depression of cardiac function by streptomycin and other antimicrobial agents. Am J Cardiol. 1970 Nov;26(5):505–511. doi: 10.1016/0002-9149(70)90708-3. [DOI] [PubMed] [Google Scholar]
  5. FISK G. C. Respiratory paralysis after a large dose of streptomycin. Report of a case. Br Med J. 1961 Feb 25;1(5225):556–557. doi: 10.1136/bmj.1.5225.556. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Goodman F. R., Weiss G. B., Adams H. R. Alterations by neomycin of 45Ca movements and contractile responses in vascular smooth muscle. J Pharmacol Exp Ther. 1974 Feb;188(2):472–480. [PubMed] [Google Scholar]
  7. Hall D. R., McGibbon D. H., Evans C. C., Meadows G. A. Gentamicin, tubocurarine, lignocaine and neuromuscular blockade. A case report. Br J Anaesth. 1972 Dec;44(12):1329–1332. doi: 10.1093/bja/44.12.1329. [DOI] [PubMed] [Google Scholar]
  8. Katz A. M., Repke D. I. Calcium-membrane interactions in the myocardium: effects of ouabain, epinephrine and 3',5'-cyclic adenosine monophosphate. Am J Cardiol. 1973 Feb;31(2):193–201. doi: 10.1016/0002-9149(73)91032-1. [DOI] [PubMed] [Google Scholar]
  9. Nayler W. G. An effect of ouabain on the superficially-located stores of calcium in cardiac muscle cells. J Mol Cell Cardiol. 1973 Feb;5(1):101–110. doi: 10.1016/0022-2828(73)90039-4. [DOI] [PubMed] [Google Scholar]
  10. Nayler W. G. Effect of inotropic agents on canine trabecular muscle rendered highly permeable to calcium. Am J Physiol. 1973 Oct;225(4):918–924. doi: 10.1152/ajplegacy.1973.225.4.918. [DOI] [PubMed] [Google Scholar]
  11. PITTINGER C. B., LONG J. P., MILLER J. R. The neuromuscular blocking action of neomycin: a concern of the anesthesiologist. Anesth Analg. 1958 Sep-Oct;37(5):276–282. [PubMed] [Google Scholar]
  12. Pittinger C. B., Eryasa Y., Adamson R. Antibiotic-induced paralysis. Anesth Analg. 1970 May-Jun;49(3):487–501. [PubMed] [Google Scholar]
  13. REAM C. R. RESPIRATORY AND CARDIAC ARREST AFTER INTRAVENOUS ADMINISTRATION OF KANAMYCIN WITH REVERSAL OF TOXIC EFFECTS BY NEOSTIGMINE. Ann Intern Med. 1963 Sep;59:384–387. doi: 10.7326/0003-4819-59-3-384. [DOI] [PubMed] [Google Scholar]
  14. Rosenblum R., Frieden J. Intravenous dopamine in the treatment of myocardial dysfunction after open-heart surgery. Am Heart J. 1972 Jun;83(6):743–748. doi: 10.1016/0002-8703(72)90204-9. [DOI] [PubMed] [Google Scholar]
  15. Warner W. A., Sanders E. Neuromuscular blockade associated with gentamicin therapy. JAMA. 1971 Feb 15;215(7):1153–1154. [PubMed] [Google Scholar]
  16. Wildenthal K., Mierzwiak D. S., Myers R. W., Mitchell J. H. Effects of acute lactic acidosis on left ventricular performance. Am J Physiol. 1968 Jun;214(6):1352–1359. doi: 10.1152/ajplegacy.1968.214.6.1352. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES