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. 1975 Aug;54(4):429–436. doi: 10.1111/j.1476-5381.1975.tb07588.x

Influence of anti-hypertensive drug treatment on vascular reactivity in spontaneously hypertensive rats.

T C Hamilton
PMCID: PMC1666682  PMID: 1174760

Abstract

1. The effect of prolonged anti-hypertensive drug treatment on the blood pressure of conscious spontaneously hypertensive rats (SH-rats), and of age-matched normotensive Sprague-Dawley rats was determined during the development of hypertension in SH-rats and in the early stages of established hypertension. A comparison of the vascular reactivity to noradrenaline (NA) and 5-hydroxytryptamine (5-HT) was also made in isolated perfused mesenteric artery preparations from treated and control SH- and Sprague-Dawley rats. 2. Chronic treatment from age 4 to 16 weeks with hydrallazine alone, or a combination of hydrallazine/hydrochlorothiazide/reserpine, ad libitum in the drinking water, prevented the development of hypertension in SH-rats and also reduced the vascular reactivity to NA and 5-HT in isolated vessel preparations from treated compared to control rats. 3. Similar drug treatments started in early established hypertension reduced blood pressure in SH-rats over the 12 week treatment period (from age 8 to 20 weeks) without affecting vascular reactivity to NA and 5-HT in the isolated vessel preparation. 4. Drug treatments had little effect on blood pressure of age-matched Sprague-Dawley rats and no effect on vascular reactivity to NA and 5-HT in the isolated perfused mesenteric artery preparation from treated compared to control rats. 5. These results indicate that the development of increased vascular reactivity and of hypertension in SH-rats occurs simultaneously and, therefore, the vascular changes may be a consequence of the structural changes induced by the raised blood pressure. 6. In established hypertension, no regression of vascular changes was observed despite prolonged reduction of blood pressure. The role of an increased vascular reactivity in the maintenance of hypertension is therefore questionable.

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Selected References

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  1. Bandick N. R., Sparks H. V. Contractile response of vascular smooth muscle of renal hypertensive rats. Am J Physiol. 1970 Aug;219(2):340–344. doi: 10.1152/ajplegacy.1970.219.2.340. [DOI] [PubMed] [Google Scholar]
  2. CONWAY J. A vascular abnormality in hypertension. A study of blood flow in the forearm. Circulation. 1963 Apr;27(4 Pt 1):520–529. doi: 10.1161/01.cir.27.4.520. [DOI] [PubMed] [Google Scholar]
  3. FOLKOW B., GRIMBY G., THULESIUS O. Adaptive structural changes of the vascular walls in hypertension and their relation to the control of the peripheral resistance. Acta Physiol Scand. 1958 Dec 15;44(3-4):255–272. doi: 10.1111/j.1748-1716.1958.tb01626.x. [DOI] [PubMed] [Google Scholar]
  4. Folkow B., Gurèvich M., Hallbäck M., Lundgren Y., Weiss L. The hemodynamic consequences of regional hypotension in spontaneously hypertensive and normotensive rats. Acta Physiol Scand. 1971 Dec;83(4):532–541. doi: 10.1111/j.1748-1716.1971.tb05111.x. [DOI] [PubMed] [Google Scholar]
  5. Folkow B., Hallbäck M., Lundgren Y., Weiss L. Background of increased flow resistance and vascular reactivity in spontaneously hypertensive rats. Acta Physiol Scand. 1970 Sep;80(1):93–106. doi: 10.1111/j.1748-1716.1970.tb04773.x. [DOI] [PubMed] [Google Scholar]
  6. Folkow B., Hallbäck M., Lundgren Y., Weiss L. Structurally based increase of flow resistance in spontaneously hypertensive rats. Acta Physiol Scand. 1970 Jul;79(3):373–378. doi: 10.1111/j.1748-1716.1970.tb04737.x. [DOI] [PubMed] [Google Scholar]
  7. Folkow B., Hallbäck M., Lundgren Y., Weiss L. The effects of "immunosympathectomy" on blood pressure and vascular "reactivity" in normal and spontaneously hypertensive rats. Acta Physiol Scand. 1972 Apr;84(4):512–523. doi: 10.1111/j.1748-1716.1972.tb05202.x. [DOI] [PubMed] [Google Scholar]
  8. Freis E. D., Ragan D., Pillsbury H., 3rd, Mathews M. Alteration of the course of hypertension in the spontaneously hypertensive rat. Circ Res. 1972 Jul;31(1):1–7. doi: 10.1161/01.res.31.1.1. [DOI] [PubMed] [Google Scholar]
  9. Haeusler G., Finch L. Vascular reactivity to 5-hydroxytryptamine and hypertension in the rat. Naunyn Schmiedebergs Arch Pharmacol. 1972;272(1):101–116. doi: 10.1007/BF00498797. [DOI] [PubMed] [Google Scholar]
  10. Hallbäck M., Lundgren Y., Weiss L. The distensibility of the resistance vessels in spontaneously hypertensive rats (SHR) as compared with normotensive control rats (NCR). Acta Physiol Scand. 1974 Jan;90(1):57–68. doi: 10.1111/j.1748-1716.1974.tb05562.x. [DOI] [PubMed] [Google Scholar]
  11. Harris G. S. Vascular reactivity to ATP in vitro in experimental hypertension. Microvasc Res. 1972 Jul;4(3):298–299. doi: 10.1016/0026-2862(72)90043-x. [DOI] [PubMed] [Google Scholar]
  12. Holloway E. T., Bohr D. F. Reactivity of vascular smooth muscle in hypertensive rats. Circ Res. 1973 Dec;33(6):678–685. doi: 10.1161/01.res.33.6.678. [DOI] [PubMed] [Google Scholar]
  13. Lundgren Y. Regression of structural cardiovascular changes after reversal of experimental renal hypertension in rats. Acta Physiol Scand. 1974 Jun;91(2):275–285. doi: 10.1111/j.1748-1716.1974.tb05683.x. [DOI] [PubMed] [Google Scholar]
  14. MCGREGOR D. D. THE EFFECT OF SYMPATHETIC NERVE STIMULATION OF VASOCONSTRICTOR RESPONSES IN PERFUSED MESENTERIC BLOOD VESSELS OF THE RAT. J Physiol. 1965 Mar;177:21–30. doi: 10.1113/jphysiol.1965.sp007572. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. OKAMOTO K., AOKI K. Development of a strain of spontaneously hypertensive rats. Jpn Circ J. 1963 Mar;27:282–293. doi: 10.1253/jcj.27.282. [DOI] [PubMed] [Google Scholar]
  16. Weiss L., Hallbäck M. Time course and extent of structural vascular adaptation to regional hypotension in adult spontaneously hypertensive rats (SHR). Acta Physiol Scand. 1974 Jul;91(3):365–373. doi: 10.1111/j.1748-1716.1974.tb05691.x. [DOI] [PubMed] [Google Scholar]
  17. Weiss L. Long-term treatment with antihypertensive drugs in spontaneously hypertensive rats (SHR). Effects on blood pressure, survival rate and cardiovascular design. Acta Physiol Scand. 1974 Jul;91(3):393–408. doi: 10.1111/j.1748-1716.1974.tb05694.x. [DOI] [PubMed] [Google Scholar]
  18. Weiss L., Lundgren Y., Folkow B. Effects of prolonged treatment with adrenergic beta-receptor antagonists on blood pressure, cardiovascular design and reactivity in spontaneously hypertensive rats (SHR). Acta Physiol Scand. 1974 Aug;91(4):447–457. doi: 10.1111/j.1748-1716.1974.tb05701.x. [DOI] [PubMed] [Google Scholar]

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