Skip to main content
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1975 Sep;55(1):41–46. doi: 10.1111/j.1476-5381.1975.tb07607.x

Mechanical responses of rat isolated uterine horns to transmural stimulation.

M Hollingsworth
PMCID: PMC1666719  PMID: 1182347

Abstract

1 Transmural stimulation of rat isolated uterine horns at low pulse width produced contractions. These were antagonized by hyoscine or tetrodotoxin and potentiated by physostigmine. 2 In the presence of hyoscine, and during bradykinin-induced contractions, transmural stimulation produced inhibition. This inhibition was antagonized by guanethidine, propranolol or tetrodotoxin. 3 Hexamethonium or pempidine did not affect responses to transmural stimulation. 4 It is suggested that transmural stimulation is a method of exciting cholinergic motor and noradrenergic inhibitory postganglionic neurones to the rat myometrium.

Full text

PDF
41

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adham N., Schenk E. A. Autonomic innervation of the rat vagina, cervix, and uterus and its cyclic cariation. Am J Obstet Gynecol. 1969 Jun 15;104(4):508–516. doi: 10.1016/s0002-9378(16)34239-9. [DOI] [PubMed] [Google Scholar]
  2. Bower E. A. The characteristics of spontaneous and evoked action potentials recorded from the rabbit's uterine nerves. J Physiol. 1966 Apr;183(3):730–747. doi: 10.1113/jphysiol.1966.sp007895. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Butterworth K. R., Randall M. J. The effects of alpha- and beta-adrenoceptor blocking agents on the responses of the rat uterus to catecholamines throughout the oestrus cycle. Br J Pharmacol. 1970 Sep;40(1):160P–161P. [PMC free article] [PubMed] [Google Scholar]
  4. Foley D. J., McPhillips J. J. Response of the rat ileum, uterus and vas deferens to carbachol and acetylcholine following repeated daily administration of a cholinesterase inhibitor. Br J Pharmacol. 1973 Jul;48(3):418–425. doi: 10.1111/j.1476-5381.1973.tb08350.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hervonen A., Kanerva L., Lietzén R. Histochemically demonstrable catecholamines and cholinesterases of the rat uterus during estrus cycle, pregnancy and after estrogen treatment. Acta Physiol Scand. 1973 Feb;87(2):283–288. doi: 10.1111/j.1748-1716.1973.tb05392.x. [DOI] [PubMed] [Google Scholar]
  6. Hollingsworth M. The innervation of the rat cervix and its pharmacology in vitro and in vivo. Br J Pharmacol. 1974 Dec;52(4):539–547. doi: 10.1111/j.1476-5381.1974.tb09722.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kanerva L., Mustonen T., Teräväinen H. Histochemical studies of uterine innervation after neurectomies. Acta Physiol Scand. 1972 Nov;86(3):359–365. doi: 10.1111/j.1748-1716.1972.tb05342.x. [DOI] [PubMed] [Google Scholar]
  8. Marshall J. M. Adrenergic innervation of the female reproductive tract: anatomy, physiology and pharmacology. Ergeb Physiol. 1970;62:6–67. doi: 10.1007/BFb0111421. [DOI] [PubMed] [Google Scholar]
  9. Mustonen T., Teräväinen H. Synaptic connections of the paracervical (Frankenhäuser) ganglion of the rat uterus examined with the electron microscope after division of the sympathetic and sacral parasympathetic nerves. Acta Physiol Scand. 1971 Jun;82(2):264–267. doi: 10.1111/j.1748-1716.1971.tb04965.x. [DOI] [PubMed] [Google Scholar]
  10. Nakanishi H., Wood C. Cholinergic mechanisms in the human uterus. J Obstet Gynaecol Br Commonw. 1971 Aug;78(8):716–723. doi: 10.1111/j.1471-0528.1971.tb01635.x. [DOI] [PubMed] [Google Scholar]
  11. PATERSON G. THE NATURE OF THE INHIBITION OF THE RAT UTERUS BY RELAXIN. J Pharm Pharmacol. 1965 Apr;17:262–264. doi: 10.1111/j.2042-7158.1965.tb07666.x. [DOI] [PubMed] [Google Scholar]
  12. Rüsse M. W., Marshall J. M. Uterine response to adrenergic nerve stimulation in the guinea pig. Biol Reprod. 1970 Aug;3(1):13–22. doi: 10.1093/biolreprod/3.1.13. [DOI] [PubMed] [Google Scholar]
  13. SCHOFIELD B. M. The innervation of the cervix and cornu uteri in the rabbit. J Physiol. 1952 Jul;117(3):317–328. doi: 10.1113/jphysiol.1952.sp004751. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. VARAGIC V. An isolated rabbit hypogastric-nerve-uterus preparation, with observations on the hypogastric transmitter. J Physiol. 1956 Apr 27;132(1):92–99. doi: 10.1113/jphysiol.1956.sp005504. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. WURTMAN R. J., CHU E. W., AXELROD J. Relation between the oestrous cycle and the binding of catecholamines in the rat uterus. Nature. 1963 May 11;198:547–548. doi: 10.1038/198547a0. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES