Abstract
The efflux of 45Ca from slices of guinea-pig and rabbit liver is greatly increased by alpha-adrenoceptor agonists. Isoprenaline is much less effective. The effects of these agents on the efflux of 45Ca mirror their actions on 42K loss and suggest that the two may be related. Glucose release from both rabbit and guinea-pig liver slices is increased to a similar extent by either alpha- or beta-receptor agonists. The possible relationship between Ca and K movements and the production of glucose is discussed.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- DUNGAN K. W., STANTON H. C., LISH P. M. AMIDEPHRINE--I: PHARMACOLOGIC CHARACTERIZATION OF A SYMPATHOMIMETIC ALKYLSULFONAMIDOPHENETHANOLAMINE. Int J Neuropharmacol. 1965 Jul;4:219–234. doi: 10.1016/0028-3908(65)90038-9. [DOI] [PubMed] [Google Scholar]
- Haylett D. G., Jenkinson D. H. Effects of noradrenaline on potassium reflux, membrane potential and electrolyte levels in tissue slices prepared from guinea-pig liver. J Physiol. 1972 Sep;225(3):721–750. doi: 10.1113/jphysiol.1972.sp009966. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Haylett D. G., Jenkinson D. H. The receptors concerned in the actions of catecholamines on glucose release, membrane potential and ion movements in guinea-pig liver. J Physiol. 1972 Sep;225(3):751–772. doi: 10.1113/jphysiol.1972.sp009967. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Heilmeyer L. M., Jr, Meyer F., Haschke R. H., Fischer E. H. Control of phosphorylase activity in a muscle glycogen particle. II. Activation by calcium. J Biol Chem. 1970 Dec 25;245(24):6649–6656. [PubMed] [Google Scholar]
- Meech R. W. The sensitivity of Helix aspersa neurones to injected calcium ions. J Physiol. 1974 Mar;237(2):259–277. doi: 10.1113/jphysiol.1974.sp010481. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Osborn D., Jenkinson D. H. Proceedings: Comparison of the effects of selective alpha and beta-receptor agonists on intracellular cyclic AMP levels and glycogen phosphorylase activity in guinea-pig liver. Br J Pharmacol. 1975 Oct;55(2):286P–287P. [PMC free article] [PubMed] [Google Scholar]
- Romero P. J., Whittam R. The control by internal calcium of membrane permeability to sodium and potassium. J Physiol. 1971 May;214(3):481–507. doi: 10.1113/jphysiol.1971.sp009445. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Selinger Z., Eimerl S., Schramm M. A calcium ionophore simulating the action of epinephrine on the alpha-adrenergic receptor. Proc Natl Acad Sci U S A. 1974 Jan;71(1):128–131. doi: 10.1073/pnas.71.1.128. [DOI] [PMC free article] [PubMed] [Google Scholar]