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. 1976 May;57(1):133–140. doi: 10.1111/j.1476-5381.1976.tb07663.x

On the actions of compounds related to dopamine at a neurosecretory synapse.

B L Ginsborg, K W Turnbull, C R House
PMCID: PMC1667013  PMID: 1276532

Abstract

1 The effects of a number of substances related to dopamine, including all its methylated derivatives, were investigated on the membrane potential and response to nerve stimulation of cockroach salivary gland cells. 2 Only N-methyldopamine (epinine), N,N-dimethyldopamine and N,N-dimethylnoradrenaline, all with unsubstituted hydroxyl groups, directly resembled dopamine in producing a hyperpolarization which could be as large as that caused by maximal nerve stimulation. During the continued presence of these substances the hyperpolarization waned and responses to nerve stimulation declined. 3 Many of the compounds caused one or both of two other effects, namely an increase in the rate of 'spontaneous miniature hyperpolarizations' and an enhancement of the submaximal responses to single nerve stimuli. There were no obvious structural requirements for these effects.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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