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. 1976 Aug;57(4):533–541. doi: 10.1111/j.1476-5381.1976.tb10381.x

Interactions of isoprenaline and prostaglandin E2 with respect to myocardial contractile force, coronary vascular resistance and myocardial oxygen consumption in guinea-pig isolated hearts.

R Krebs, K Schrör
PMCID: PMC1667030  PMID: 963342

Abstract

Left ventricular pressure (LVP), left ventricular pressure derivative (LV dp/dtmax), coronary vascular resistance (CVR) and myocardial oxygen consumption (Qo2) were measured simultaneously in isolated, electrically driven hearts of guinea-pigs at constant perfusion rate. 2 LVP, LV dp/dtmax, CVR and Qo2 were greatly decreased by either the addition of prostaglandin E2 (50 ng/ml) to the perfusion fluid or pretreatment of the animals with reserpine. 3 Isoprenaline (0.5 nM to 100 nM) induced increases in LVP, LV dp/dtmax and Qo2. In the presence of prostaglandin E2, there was a parallel shift of the isoprenaline concentration-response curve for LVP and LV dp/dtmax. This effect was not seen, after the animals had been treated with reserpine. 4 Qo2 was also decreased by prostaglandin E2 only in non-reserpine treated animals. 5 CVR was diminished by isoprenaline in the untreated group. However, there was increase in CVR, when isoprenaline was added to either prostaglandin E2 or reserpine-pretreated hearts which was enhanced in the reserpine plus prostaglandin E2-treated group (P less than 0.01). 6 The results give evidence for different actions of prostaglandin E2 on isoprenaline concentration-response curves for LVP, LV dp/dtmax and CVR.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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