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. 1976 Aug;57(4):527–532. doi: 10.1111/j.1476-5381.1976.tb10380.x

Effect of ionizing radiation on prostaglandin-like activity in tissues.

V Eisen, D I Walker
PMCID: PMC1667034  PMID: 963341

Abstract

One to 7 days after whole body exposure of mice to a single dose of 700 R of x-rays, little or no change was detected in prostaglandin-like activity in the brain, blood and seminal vesicles. Slight increases in intestinal and renal tissue were not significant. In the lung, mean activity rose from 62 ng/g to a transient peak of 145 ng/g wet weight on the fourth day (P less than 0.05). In the spleen, mean levels rose steadily from 13.2 ng/g to 259 ng/g on the fourth day (P less than 0.01), and were still 184.4 ng/g on the seventh day. 2 Prostaglandin-like activity was measured 4 days after single doses of 200-700 R. In the lung, a significant rise was produced by 600 and 700 R, and in the spleen by 200-700 R. 3 Thin layer chromatography showed that part of the prostaglandin-like activity in spleen extracts had RF similar to that of [3H]-prostaglandin E1, and part to that of [3H]-prostaglandin F2alpha. 4 Splenic tissue from mice exposed to 700 R four days earlier, inactivated prostaglandin E1 less potently than did tissue from non-irradiated mice.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BERTALANFFY F. D., LEBLOND C. P. The continuous renewal of the two types of alveolar cells in the lung of the rat. Anat Rec. 1953 Mar;115(3):515–541. doi: 10.1002/ar.1091150306. [DOI] [PubMed] [Google Scholar]
  2. Bedwani J. R., Marley P. B. Enhanced inactivation of prostaglandin E2 by the rabbit lung during pregnancy or progesterone treatment. Br J Pharmacol. 1975 Apr;53(4):547–554. doi: 10.1111/j.1476-5381.1975.tb07393.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Blackwell G. J., Flower R. J., Vane J. R. Rapid reduction of prostaglandin 15-hydroxy dehydrogenase activity in rat tissues after treatment with protein synthesis inhibitors. Br J Pharmacol. 1975 Oct;55(2):233–238. doi: 10.1111/j.1476-5381.1975.tb07633.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Fehér I., Gidáli J. Prostaglandin E2 as stimulator of haemopoietic stem cell proliferation. Nature. 1974 Feb 22;247(5442):550–551. doi: 10.1038/247550a0. [DOI] [PubMed] [Google Scholar]
  5. Flower R. J. Drugs which inhibit prostaglandin biosynthesis. Pharmacol Rev. 1974 Mar;26(1):33–67. [PubMed] [Google Scholar]
  6. GREEN K., SAMUELSSON B. PROSTAGLANDINS AND RELATED FACTORS: XIX. THIN-LAYER CHROMATOGRAPHY OF PROSTAGLANDINS. J Lipid Res. 1964 Jan;5:117–120. [PubMed] [Google Scholar]
  7. Gilmore N., Vane J. R., Wyllie J. H. Prostaglandins released by the spleen. Nature. 1968 Jun 22;218(5147):1135–1140. doi: 10.1038/2181135a0. [DOI] [PubMed] [Google Scholar]
  8. Greaves M. W., McDonald-Gibson W. Extraction of prostaglandin-like activity from whole human blood. Life Sci I. 1972 Jan 15;11(2):73–81. doi: 10.1016/0024-3205(72)90165-8. [DOI] [PubMed] [Google Scholar]
  9. Harris J. O., Swenson E. W., Johnson J. E., 3rd Human alveolar macrophages: comparison of phagocytic ability, glucose utilization, and ultrastructure in smokers and nonsmokers. J Clin Invest. 1970 Nov;49(11):2086–2096. doi: 10.1172/JCI106426. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Higgs G. A., McCall E., Youlten L. J. A chemotactic role for prostaglandins released from polymorphonuclear leucocytes during phagocytosis. Br J Pharmacol. 1975 Apr;53(4):539–546. doi: 10.1111/j.1476-5381.1975.tb07392.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Jordan S. W. Ultrastructural studies of spleen after whole body irradiation of mice. Exp Mol Pathol. 1967 Apr;6(2):156–171. doi: 10.1016/0014-4800(67)90053-6. [DOI] [PubMed] [Google Scholar]
  12. Kirtland S. J., Baum H. Prostaglandin E 1 may act as a "calcium ionophore". Nat New Biol. 1972 Mar 15;236(63):47–49. doi: 10.1038/newbio236047a0. [DOI] [PubMed] [Google Scholar]
  13. Mennie A. T., Dalley V. M., Dinneen L. C., Collier H. O. Treatment of radiation-induced gastrointestinal distress with acetylsalicylate. Lancet. 1975 Nov 15;2(7942):942–943. doi: 10.1016/s0140-6736(75)90358-x. [DOI] [PubMed] [Google Scholar]
  14. Prasad K. N. Radioprotective effect of prostaglandin and an inhibitor of cyclic nucleotide phosphodiesterase on mammalian cells in culture. Int J Radiat Biol Relat Stud Phys Chem Med. 1972 Aug;22(2):187–189. [PubMed] [Google Scholar]
  15. Unger W. G., Stamford I. F., Bennett A. Extraction of prostaglandins from human blood. Nature. 1971 Oct 1;233(5318):336–337. doi: 10.1038/233336b0. [DOI] [PubMed] [Google Scholar]
  16. VANE J. R. A sensitive method for the assay of 5-hydroxytryptamine. Br J Pharmacol Chemother. 1957 Sep;12(3):344–349. doi: 10.1111/j.1476-5381.1957.tb00146.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Vane J. R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol. 1971 Jun 23;231(25):232–235. doi: 10.1038/newbio231232a0. [DOI] [PubMed] [Google Scholar]
  18. Vane J. R. The release and fate of vaso-active hormones in the circulation. Br J Pharmacol. 1969 Feb;35(2):209–242. doi: 10.1111/j.1476-5381.1969.tb07982.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

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