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. 1976 Aug;57(4):547–550. doi: 10.1111/j.1476-5381.1976.tb10383.x

Stereospecific actions of 2,5-dimethoxy-4-methylamphetamine (DOM) on colonic temperature in the rat at various ambient temperatures.

J M Beaton, F Benington, R J Bradley, K V Kuhlemeier, R D Morin
PMCID: PMC1667035  PMID: 134754

Abstract

The R(-) and S(+)-isomers of 2,5-dimethoxy-4-methylamphetamine (DOM) produce a dose-dependent hypothermia in rats kept in the cold (6 degrees C). 2 This hypothermia was linearly dependent upon ambient temperature and the R(-)-isomer was considerably more potent than the S(+)-isomer. 3 A statistically significant tachyphylaxis was observed when R(-)-DOM was administered on two successive days. The response seven days after the second injection was similar to that on the first day of injection. 4 The hypothermia induced by R(-) and S(+)-DOM was antagonized by methysergide but not by p-chlorophenylalanine (PCPA) or pimozide. Methysergide, PCPA or pimozide alone did not elicit hypothermia at the doses used. The results indicate that R(-) and S(+)-DOM act at post-synaptic 5-hydroxytryptamine receptors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Benington F., Morin R. D., Beaton J., Smythies J. R., Bradley R. J. Comparative effects of stereoisomers of hallucinogenic amphetamines. Nat New Biol. 1973 Apr 11;242(119):185–186. doi: 10.1038/newbio242185a0. [DOI] [PubMed] [Google Scholar]
  2. Cheng H. C., Long J. P., Barfknecht C. F., Nichols D. E. Cardiovascular effects of 2, 5-dimethoxy-4-methylamphetamine (DOM, STP). J Pharmacol Exp Ther. 1973 Aug;186(2):345–354. [PubMed] [Google Scholar]
  3. Hollister L. E., Macnicol M. F., Gillespie H. K. An hallucinogenic amphetamine analog (DOM) in man. Psychopharmacologia. 1969;14(1):62–73. doi: 10.1007/BF00401535. [DOI] [PubMed] [Google Scholar]
  4. MORPURGO C., THEOBALD W. INFLUENCE OF IMPIRAMINE-LIKE COMPOUNDS AND CHLORPROMAZINE ON THE RESERPINE-HYPOTHERMIA IN MICE AND THE AMPHETAMINE-HYPERTHERMIA IN RATS. Med Pharmacol Exp Int J Exp Med. 1965;12:226–232. doi: 10.1159/000135553. [DOI] [PubMed] [Google Scholar]
  5. Morin R. D., Benington F., Mitchell S. R., Beaton J. M., Bradley R. J., Smythies J. R. The behavioral effects of 2,5-dimethoxy-4-alkyl amphetamines. Experientia. 1975 Jan 15;31(1):93–95. doi: 10.1007/BF01924697. [DOI] [PubMed] [Google Scholar]
  6. Nichols D. E., Barfknecht C. F., Rusterholz D. B., Benington F., Morin R. D. Asymmetric synthesis of psychotomimetic phenylisopropylamines. J Med Chem. 1973 May;16(5):480–483. doi: 10.1021/jm00263a013. [DOI] [PubMed] [Google Scholar]
  7. Snyder S. H., Unger S., Blatchley R., Barfknecht C. F. Stereospecific actions of DOET (2,5-dimethoxy-4-ethylamphetamine) in man. Arch Gen Psychiatry. 1974 Jul;31(1):103–106. doi: 10.1001/archpsyc.1974.01760130079013. [DOI] [PubMed] [Google Scholar]
  8. Wallach M. B., Friedman E., Gershon S. 2,5-Dimethoxy-4-methylamphetamine (DOM), a neuropharmacological examination. J Pharmacol Exp Ther. 1972 Jul;182(1):145–154. [PubMed] [Google Scholar]
  9. Yehuda S., Wurtman R. J. Release of brain dopamine as the probable mechanism for the hypothermic effect of D-amphetamine. Nature. 1972 Dec 22;240(5382):477–478. doi: 10.1038/240477a0. [DOI] [PubMed] [Google Scholar]
  10. Yehuda S., Wurtman R. J. The effects of D-amphetamine and related drugs on colonic temperatures of rats kept at various ambient temperatures. Life Sci I. 1972 Sep 15;11(18):851–859. doi: 10.1016/0024-3205(72)90101-4. [DOI] [PubMed] [Google Scholar]

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