Abstract
The pharmacology of spontaneously active cholinoceptive neurones in the brain stem of rats anaesthetized with urethane has been investigated using microiontophoresis to administer muscarinic and nicotinic agonists and antagonists. 2. Acetylcholine (ACh) excited most cells but occasionally depressed their activity. Muscarine, and the muscarinic agonists methacholine and bethanechol produced prolonged excitation or inhibition of cells whereas nicotine produced prolonged excitations but no inhibitions. 3 Atropine selectively antagonized ACh excitations and both excitation and inhibition of neuronal activity produced by muscarine and muscarinic agonists, but not the excitations produced by nicotine, glutamate or DL-homocysteic acid. 4 Dihydro-beta-erythroidine (DHBE) and tubocurarine antagonized both ACh and nicotine excitations but not those induced by glutamate or DL-homocysteic acid. Inhibitions by ACh or muscarine were not affected. 5 It is concluded that excitations of cholinoceptive neurones in the rat brain stem may be mediated by activation of both muscarinic and nicotinic receptors whereas inhibitions are mediated by activation of a muscarinic receptor.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Avanzino G. L., Bradley P. B., Wolstencroft J. H. Pharmacological properties of neurons of the paramedian reticular nucleus. Experientia. 1966 Jun 15;22(6):410–410. doi: 10.1007/BF01901170. [DOI] [PubMed] [Google Scholar]
- Bradley P. B., Dhawan B. N., Wolstencroft J. H. Pharmacological properties of cholinoceptive neurones in the medulla and pons of the cat. J Physiol. 1966 Apr;183(3):658–674. doi: 10.1113/jphysiol.1966.sp007891. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bradley P. B., Dray A. Modification of the responses of brain stem neurones to transmitter substances by anaesthetic agents. Br J Pharmacol. 1973 Jun;48(2):212–224. doi: 10.1111/j.1476-5381.1973.tb06907.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bradley P. B., Dray A. Short-latency excitation of brain stem neurones in the rat by acetylcholine. Br J Pharmacol. 1972 Jun;45(2):372–374. doi: 10.1111/j.1476-5381.1972.tb08091.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Duggan A. W., Headley P. M., Lodge D. Acetylcholine-sensitive cells in the caudal medulla of the rat: distribution, pharmacology and effects of pentobarbitone. Br J Pharmacol. 1975 May;54(1):23–31. doi: 10.1111/j.1476-5381.1975.tb07405.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McCance I., Phillis J. W., Westerman R. A. Acetylcholine-sensitivity of thalamic neurones: its relationship to synaptic transmission. Br J Pharmacol Chemother. 1968 Mar;32(3):635–651. doi: 10.1111/j.1476-5381.1968.tb00463.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tebecis A. K. Properties of cholinoceptive neurones in the medial geniculate nucleus. Br J Pharmacol. 1970 Jan;38(1):117–137. doi: 10.1111/j.1476-5381.1970.tb10341.x. [DOI] [PMC free article] [PubMed] [Google Scholar]