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. 1976 Aug;57(4):521–526. doi: 10.1111/j.1476-5381.1976.tb10379.x

Calcium depletion of synaptosomes after morphine treatment.

H L Cardenas, D H Ross
PMCID: PMC1667044  PMID: 963340

Abstract

It was confirmed that morphine administration in vivo produced a selective decrease in the calcium content of synaptosomal fractions prepared from rat cerebral cortices. This effect was prevented by naloxone. 2 After morphine or naloxone, there were no changes in the sodium, potassium and magnesium contents of any of the seven subcellular fractions tested. 3 Since the selective calcium loss was found to occur from fractions similar to those reported to exhibit opiate receptor binding, it is concluded that calcium may play a role in the action of narcotic agonist drugs.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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