Abstract
Surugatoxin (SGTX, 0.1-2 muM) reversibly depressed orthodromic transmission and antagonized the depolarizing action of carbachol on the isolated superior cervical ganglion of the rat. The apparent dissociation equilibrium constant against carbachol-induced depolarization (measured in the presence of hyoscine) was 58 and 76 nM determined at 0.2 and 2 muM respectively. SGTX (2muM) did not reduce the depolarizing effects of (+/-)-muscarine, gamma-aminobutyric acid or angiotensin, but did reduce that to 5-hydroxytryptamine. Release of [3H]-acetylcholine following repetitive (10 Hz) preganglionic sympathetic stimulation was maintained in the presence of 2 muM SGTX. It is concluded that SGTX has a high and selective affinity for ganglionic nicotinic receptors.
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Selected References
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- Brown D. A., Jones K. B., Halliwell J. V., Quilliam J. P. Evidence against a presynaptic action of acetylcholine during ganglionic transmission. Nature. 1970 Jun 6;226(5249):958–959. doi: 10.1038/226958a0. [DOI] [PubMed] [Google Scholar]
- Hayashi E., Yamada S. Pharmacological studies on surugatoxin, the toxic principle from Japanese ivory mollusc (Babylonia japonica). Br J Pharmacol. 1975 Feb;53(2):207–215. doi: 10.1111/j.1476-5381.1975.tb07350.x. [DOI] [PMC free article] [PubMed] [Google Scholar]