Skip to main content
NCBI home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1971 Jun;42(2):287–297. doi: 10.1111/j.1476-5381.1971.tb07110.x

Effect of diuretics on mouse blood sugar following single dose administration

J M Foy, B L Furman
PMCID: PMC1667152  PMID: 5091161

Abstract

1. Frusemide, in doses which were maximal or supramaximal in respect of its natriuretic, diuretic and kaliuretic properties, produced a dose dependent, transient hyperglycaemic response in the mouse.

2. Bilateral nephrectomy resulted in a complete abolition of the hyperglycaemic response.

3. The hyperglycaemic response was accompanied by a decrease in liver glycogen and was significantly attenuated by adrenalectomy, adrenal demedullation and pretreatment with dihydroergotamine (DHE).

4. In the nephrectomized mouse frusemide treatment produced a marked reduction in intravenous glucose tolerance and a reduction in the plasma concentration of immunoreactive insulin following glucose administration. The drug had no detectable effect upon insulin sensitivity.

5. Hydrochlorothiazide exerted no detectable effect on mouse blood sugar.

6. Ethacrynic acid hyperglycaemia was obtainable after intraperitoneal or intramuscular injection, but not after intravenous injection. Intravenously administered ethacrynic acid exerted no effect upon intravenous glucose tolerance or insulin sensitivity in the nephrectomized mouse.

Full text

PDF
287

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersen O. O., Persson I. Carbohydrate metabolism during treatment with chlorthalidone and ethacrynic acid. Br Med J. 1968 Jun 29;2(5608):798–801. doi: 10.1136/bmj.2.5608.798. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Breckenridge A., Welborn T. A., Dollery C. T., Fraser R. Glucose tolerance in hypertensive patients on long-term diuretic therapy. Lancet. 1967 Jan 14;1(7481):61–64. doi: 10.1016/s0140-6736(67)92470-1. [DOI] [PubMed] [Google Scholar]
  3. Dige-Petersen H. Antidiuretisk effekt af etakrynsyre. Sammenligning med tiazid hos en patient med hypofysaer diabetes insipidus. Nord Med. 1966 Feb 3;75(5):125–127. [PubMed] [Google Scholar]
  4. Feldman E., Diamond S. Ethacrynic acid: a non-diabetogenic diuretic. Dis Chest. 1967 Mar;51(3):282–287. doi: 10.1378/chest.51.3.282. [DOI] [PubMed] [Google Scholar]
  5. Formanek K., Kenner T. Special features of the action of a new diuretic. Br J Pharmacol Chemother. 1966 Jan;26(1):27–33. doi: 10.1111/j.1476-5381.1966.tb01807.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Foy J. M. Acute diuretic induced hyperglycaemia in rats. Life Sci. 1967 May 1;6(9):897–902. doi: 10.1016/0024-3205(67)90074-4. [DOI] [PubMed] [Google Scholar]
  7. Foy J. M., Furman B. L. Ethacrynic acid hyperglycemia in mice. Experientia. 1967 Dec 15;23(12):1039–1040. doi: 10.1007/BF02136436. [DOI] [PubMed] [Google Scholar]
  8. GOLDNER M. G., ZAROWITZ H., AKGUN S. Hyperglycemia and glycosuria due to thiazide derivatives administered in diabetes mellitus. N Engl J Med. 1960 Feb 25;262:403–405. doi: 10.1056/NEJM196002252620807. [DOI] [PubMed] [Google Scholar]
  9. Guidoux R. Effets diabétogènes des diurétiques thiazidiques et du solvant N-monométhylamide de l'acide acétique chez le rat. Diabetologia. 1969 Feb;5(1):11–21. doi: 10.1007/BF01212213. [DOI] [PubMed] [Google Scholar]
  10. HALES C. N., RANDLE P. J. Immunoassay of insulin with insulin-antibody precipitate. Biochem J. 1963 Jul;88:137–146. doi: 10.1042/bj0880137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Haslewood G. A., Strookman T. A. A method for the estimation of "true" sugar in 0.05 ml. of blood. Biochem J. 1939 Jun;33(6):920–923. doi: 10.1042/bj0330920. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hutcheon D. E., Leonard G. Diuretic and antihypertensive actions of furosemide. J Clin Pharmacol J New Drugs. 1967 Jan-Feb;7(1):26–33. doi: 10.1002/j.1552-4604.1967.tb00026.x. [DOI] [PubMed] [Google Scholar]
  13. Jackson W. P., Nellen M. Effect of frusemide on carbohydrate metabolism, blood-pressure, and other modalities. A comparison with chlorothiazide. Br Med J. 1966 Aug 6;2(5509):333–336. doi: 10.1136/bmj.2.5509.333. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Jones I. G., Pickens P. T. Diabetes mellitus following oral diuretics. Practitioner. 1967 Aug;199(190):209–210. [PubMed] [Google Scholar]
  15. Kennedy B. L., Ellis S. Interactions of catecholamines and adrenergic blocking agents at receptor sites mediating glycogenolysis in the rat. Arch Int Pharmacodyn Ther. 1969 Feb;177(2):390–406. [PubMed] [Google Scholar]
  16. Lebacq E., Marcq M. A study of the mechanism of ethacrynic acid induced hyperglycemia. Rev Fr Etud Clin Biol. 1967 Feb;12(2):160–162. [PubMed] [Google Scholar]
  17. Loubatières A., Mariani M. M., Alric R. The action of diazoxide on insulin secretion, medullo-adrenal secretion, and the liberation of catecholamines. Ann N Y Acad Sci. 1968 Apr 11;150(2):226–241. doi: 10.1111/j.1749-6632.1968.tb19048.x. [DOI] [PubMed] [Google Scholar]
  18. MONTGOMERY R. Determination glycogen. Arch Biochem Biophys. 1957 Apr;67(2):378–386. doi: 10.1016/0003-9861(57)90292-8. [DOI] [PubMed] [Google Scholar]
  19. Ozen M. A., Sandalci O., Berker F. Ethacrynic acid and carbohydrate metabolism. Am J Med Sci. 1966 Nov;252(5):558–563. [PubMed] [Google Scholar]
  20. SCHAEFER H. F. MODERNE DIURETIKA UND IHRE NEBENWIRKUNGEN BEIM DIABETES MELLITUS. Med Welt. 1964 Apr 18;16:922–926. [PubMed] [Google Scholar]
  21. Tabachnick I. I., Gulbenkian A., Yannell A. The hyperglycemic activity of benzothiadiazine and other diuretics. Life Sci. 1965 Oct;4(20):1931–1936. doi: 10.1016/0024-3205(65)90048-2. [DOI] [PubMed] [Google Scholar]
  22. Toivonen S., Mustala O. Diabetogenic action of frusemide. Br Med J. 1966 Apr 9;1(5492):920–921. doi: 10.1136/bmj.1.5492.920-c. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. WELLER J. M., BORONDY P. E. EFFECTS OF BENZOTHIADIAZINE DRUGS ON CARBOHYDRATE METABOLISM. Metabolism. 1965 Jun;14:708–714. doi: 10.1016/0026-0495(65)90054-5. [DOI] [PubMed] [Google Scholar]
  24. WILKINS R. W. New drugs for the treatment of hypertension. Ann Intern Med. 1959 Jan;50(1):1–10. doi: 10.7326/0003-4819-50-1-1. [DOI] [PubMed] [Google Scholar]
  25. Wales J. K., Grant A., Wolff F. W. Studies on the hyperglycemic effects of nonthiazide diuretics. J Pharmacol Exp Ther. 1968 Jan;159(1):229–235. [PubMed] [Google Scholar]
  26. Zamrazil V., Dvorák V., Oskera J., Zamrazilová E. The influence of hydrochlorothiazide upon glucose tolerance test after prednisone. Metabolism. 1967 May;16(5):445–450. doi: 10.1016/0026-0495(67)90135-7. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES