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. 1971 Jun;42(2):305–307. doi: 10.1111/j.1476-5381.1971.tb07113.x

Action of bradykinin potentiating factor (BPF) and dimercaprol (BAL) on the responses to bradykinin of isolated preparations of rat intestines

A Camargo, S H Ferreira
PMCID: PMC1667156  PMID: 5091164

Abstract

BPF and BAL inhibited kininase activity of homogenates of rat intestine. However, BFP potentiated and BAL inhibited the contractions induced by bradykinin on rat isolated duodenum (low calcium solution) and terminal ileum (normal calcium solution). Neither BPF nor BAL affects the relaxation induced by bradykinin of rat duodenum bathed in normal Tyrode. These results suggest that two different types of pharmacological receptor are involved in the action of bradykinin on rat intestine, and that other factors besides the inhibition of agonist destruction participate in the mechanism of potentiation of kinin action by BPF.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Antonio A. The relaxing effect of bradykinin on intestinal smooth muscle. Br J Pharmacol Chemother. 1968 Jan;32(1):78–86. doi: 10.1111/j.1476-5381.1968.tb00431.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Auerswald W., Doleschel W. On the potentiation of kinins by sulfhydrylic compounds. Arch Int Pharmacodyn Ther. 1967 Jul;168(1):188–198. [PubMed] [Google Scholar]
  3. Cîrstea M. Potentiation of some bradykinin effects by thiol compounds. Br J Pharmacol Chemother. 1965 Oct;25(2):405–410. doi: 10.1111/j.1476-5381.1965.tb02059.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. FERREIRA S. H. A BRADYKININ-POTENTIATING FACTOR (BPF) PRESENT IN THE VENOM OF BOTHROPS JARARCA. Br J Pharmacol Chemother. 1965 Feb;24:163–169. doi: 10.1111/j.1476-5381.1965.tb02091.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. FERREIRA S. H., ROCHA E SILVA M. Potentiation of bradykinin by dimercaptopropanol (bal) and other inhibitors of its destroying enzyme in plasma. Biochem Pharmacol. 1962 Dec;11:1123–1128. doi: 10.1016/0006-2952(62)90190-9. [DOI] [PubMed] [Google Scholar]
  6. Ferreira S. H., Bartelt D. C., Greene L. J. Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom. Biochemistry. 1970 Jun 23;9(13):2583–2593. doi: 10.1021/bi00815a005. [DOI] [PubMed] [Google Scholar]
  7. Ferreira S. H., Rocha e Silva M. Potentiation of bradykinin and eledoisin by BPF (bradykinin potentiating factor) from Bothrops jararaca venom. Experientia. 1965 Jun 15;21(6):347–349. doi: 10.1007/BF02144709. [DOI] [PubMed] [Google Scholar]
  8. Ferreira S. H., Vane J. R. The disappearance of bradykinin and eledoisin in the circulation and vascular beds of the cat. Br J Pharmacol Chemother. 1967 Jun;30(2):417–424. doi: 10.1111/j.1476-5381.1967.tb02148.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. GADDUM J. H., HORTON E. W. The extraction of human urinary kinin (substance Z) and its relation to the plasma kinins. Br J Pharmacol Chemother. 1959 Mar;14(1):117–124. doi: 10.1111/j.1476-5381.1959.tb00937.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. MONOD J., CHANGEUX J. P., JACOB F. Allosteric proteins and cellular control systems. J Mol Biol. 1963 Apr;6:306–329. doi: 10.1016/s0022-2836(63)80091-1. [DOI] [PubMed] [Google Scholar]
  11. Ryan J. W., Roblero J., Stewart J. M. Inactivation of bradykinin in the pulmonary circulation. Biochem J. 1968 Dec;110(4):795–797. doi: 10.1042/bj1100795. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Sherman W. T., Gautieri R. F. Cardiovascular and gastrointestinal effects of bradykinin and its potentiation by thiols in rats. J Pharm Sci. 1969 Aug;58(8):971–975. doi: 10.1002/jps.2600580814. [DOI] [PubMed] [Google Scholar]

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