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. 1977 May;60(1):155–160. doi: 10.1111/j.1476-5381.1977.tb16760.x

Comparative effects of glyceryl trinitrate on venous and arterial smooth muscle in vitro; relevance to antianginal activity.

J E Mackenzie, J R Parratt
PMCID: PMC1667181  PMID: 406960

Abstract

1. A quantitative in vitro study has been made of the actions of glyceryl trinitrate and sodium nitrite on vascular smooth muscle (dog femoral artery and saphenous vein; rat portal vein); these have been compared with the actions of papaverine, isoprenaline, salbutamol, pentaerythritol tetranitrate and trimetazidine. 2. Glyceryl trinitrate was more active on the saphenous vein than on the femoral artery in inhibiting noradrenaline and potassium-induced tone. 3. Unlike glyceryl trinitrate, sodium nitrite and isoprenaline, papaverine and diazoxide inhibited noradrenaline-induced contractions of venous and arterial smooth muscle to the same extent. 4. The selective dilator effects of glyceryl trinitrate on venous smooth muscle may explain its action in alleviating the pain of angina pectoris. It is suggested that the use of these three vascular smooth muscle preparations (arterial, and veins with and without spontaneous myogenic activity) is a useful initial screening procedure for prospective antianginal drugs acting by venodilatation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ABLAD B., MELLANDER S. COMPARATIVE EFFECTS OF HYDRALAZINE, SODIUM NITRITE AND ACETYLCHOLINE ON RESISTANCE AND CAPACITANCE BLOOD VESSELS AND CAPILLARY FILTRATION IN SKELETAL MUSCLE IN THE CAT. Acta Physiol Scand. 1963 Aug;58:319–329. doi: 10.1111/j.1748-1716.1963.tb02654.x. [DOI] [PubMed] [Google Scholar]
  2. Andersson R. Role of cyclic AMP and Ca ++ in mechanical and metabolic events in isometrically contracting vascular smooth muscle. Acta Physiol Scand. 1973 Jan;87(1):84–95. doi: 10.1111/j.1748-1716.1973.tb05369.x. [DOI] [PubMed] [Google Scholar]
  3. Cyong J. C., Tanaka K., Horiguchi Y., Tsuchiya R., Itoh H. Mechanism of decreased venous return with nitroglycerin. Jpn J Pharmacol. 1976 Feb;(1):123–125. doi: 10.1254/jjp.26.123. [DOI] [PubMed] [Google Scholar]
  4. Hirshfeld J. W., Jr, Borer J. S., Goldstein R. E., Barrett M. J., Epstein S. E. Reduction in severity and extent of myocardial infarction when nitroglycerin and methoxamine are administered during coronary occlusion. Circulation. 1974 Feb;49(2):291–297. doi: 10.1161/01.cir.49.2.291. [DOI] [PubMed] [Google Scholar]
  5. Johnsson G., Oberg B. Comparative effects of isoprenaline and nitroglycerin on consecutive vascular sections in the skeletal muscle of the cat. Angiologica. 1968;5(3):161–171. [PubMed] [Google Scholar]
  6. Lee S. J., Sung Y. K., Zaragoza A. J. Effects of nitroglycerin on left ventricular volumes and wall tension in patients with ischaemic heart disease. Br Heart J. 1970 Nov;32(6):790–794. doi: 10.1136/hrt.32.6.790. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Levy B., Wilkenfeld B. E. The potentiation of rat uterine inhibitory responses to noradrenaline by theophylline and nitroglycerine. Br J Pharmacol. 1968 Nov;34(3):604–612. doi: 10.1111/j.1476-5381.1968.tb08489.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. MELLANDER S. Comparative studies on the adrenergic neuro-hormonal control of resistance and capacitance blood vessels in the cat. Acta Physiol Scand Suppl. 1960;50(176):1–86. [PubMed] [Google Scholar]
  9. Mason D. T., Braunwald E. The effects of nitroglycerin and amyl nitrite on arteriolar and venous tone in the human forearm. Circulation. 1965 Nov;32(5):755–766. doi: 10.1161/01.cir.32.5.755. [DOI] [PubMed] [Google Scholar]
  10. Parratt J. R. Pharmacological approaches to the therapy of angina. Adv Drug Res. 1974;9:103–134. [PubMed] [Google Scholar]
  11. Pöch G., Kukovetz W. R. Studies on the possible role of cyclic AMP in drug-induced coronary vasodilatation. Adv Cyclic Nucleotide Res. 1972;1:195–211. [PubMed] [Google Scholar]
  12. Robinson B. F. Mechanisms in angina pectoris in relation to drug therapy. Adv Drug Res. 1975;10:93–100. [PubMed] [Google Scholar]
  13. Smith E. R., Redwood D. R., McCarron W. E., Epstein S. E. Coronary artery occlusion in the conscious dog. Effects of alterations in arterial pressure produced by nitroglycerin, hemorrhage, and alpha-adrenergic agonists on the degree of myocardial ischemia. Circulation. 1973 Jan;47(1):51–57. doi: 10.1161/01.cir.47.1.51. [DOI] [PubMed] [Google Scholar]
  14. Williams J. F., Jr, Glick G., Braunwald E. Studies on cardiac dimensions in intact unanesthetized man. V. Effects of nitroglycerin. Circulation. 1965 Nov;32(5):767–771. doi: 10.1161/01.cir.32.5.767. [DOI] [PubMed] [Google Scholar]

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