Skip to main content
NCBI home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1977 May;60(1):73–76. doi: 10.1111/j.1476-5381.1977.tb16749.x

Intrarenal stimulation of renin secretion by frusemide in the isolated kidney of the rat.

R Vandongen
PMCID: PMC1667191  PMID: 884392

Abstract

1. Intrarenal infusion of frusemide markedly stimulated renin secretion in the isolated perfused kidney of the rat. 2. Renin vales increased from 24+/-6 to 195+/-34 units of secretion rate (renin concentration (nmol angiotensin I/h per litre) X flow rate (ml/min)) following administration of frusemide for 8 min, compared with corresponding control values of 13 +/- 2 (P greater than 0.05) and 47 +/-18 (P less than 0.001). This stimulatory effect was also observed when urine flow was interrupted by ligation of the ureters. 3. The changes in renal perfusion pressure and perfusate flow rate were not significantly differnt from the control values. 4. These findings indicate the existence of an intrarenal site of action for frusemide on renin secretion. 5. Since frusemide did dot appear to alter perfusion pressure or flow rate, and was effective when urine flow was abolished, a dominant role for a vascular or macula densa receptor mechnaism seems unlikely. A direct effect of frusemide on the renin secreting cell is therefore suggested.

Full text

PDF
73

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bailie M. D., Davis L. E., Loutzenhiser R. Intrarenal secretion of renin in the dog: effect of furosemide. Am J Physiol. 1973 Feb;224(2):425–430. doi: 10.1152/ajplegacy.1973.224.2.425. [DOI] [PubMed] [Google Scholar]
  2. Birtch A. G., Zakheim R. M., Jones L. G., Barger A. C. Redistribution of renal blood flow produced by furosemide and ethacrynic acid. Circ Res. 1967 Dec;21(6):869–878. doi: 10.1161/01.res.21.6.869. [DOI] [PubMed] [Google Scholar]
  3. Blaine E. H., Davis J. O., Witty R. T. Renin release after hemorrhage and after suprarenal aortic constriction in dogs without sodium delivery to the macula densa. Circ Res. 1970 Dec;27(6):1081–1089. doi: 10.1161/01.res.27.6.1081. [DOI] [PubMed] [Google Scholar]
  4. Boyd G. W., Fitz A. E., Adamson A. R., Peart W. S. Radioimmunoassay determination of plasma-renin activity. Lancet. 1969 Feb 1;1(7588):213–218. doi: 10.1016/s0140-6736(69)91237-9. [DOI] [PubMed] [Google Scholar]
  5. Corsini W. A., Hook J. B., Bailie M. D. Control of renin secretion in the dog. Effects of furosemide on the vascular and macula densa receptors. Circ Res. 1975 Oct;37(4):464–470. doi: 10.1161/01.res.37.4.464. [DOI] [PubMed] [Google Scholar]
  6. Fraser R., James V. H., Brown J. J., Isaac P., Lever A. F., Robertson J. I. Effect of angiotensin and of frusemide on plasma aldosterone, corticosterone, cortisol and renin in man. Lancet. 1965 Nov 13;2(7420):989–991. doi: 10.1016/s0140-6736(65)92847-3. [DOI] [PubMed] [Google Scholar]
  7. Gordon R. D., Küchel O., Liddle G. W., Island D. P. Role of the sympathetic nervous system in regulating renin and aldosterone production in man. J Clin Invest. 1967 Apr;46(4):599–605. doi: 10.1172/JCI105561. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hesse B., Nielsen I., Lund-Jacobsen H. The early effects of intravenous frusemide on central haemodynamics, venous tone and plasma renin activity. Clin Sci Mol Med. 1975 Dec;49(6):551–555. doi: 10.1042/cs0490551. [DOI] [PubMed] [Google Scholar]
  9. Hook J. B., Blatt A. H., Brody M. J., Williamson H. E. Effects of several saluretic-diuretic agents on renal hemodynamics. J Pharmacol Exp Ther. 1966 Dec;154(3):667–673. [PubMed] [Google Scholar]
  10. Kaloyanides G. J., Bastron R. D., DiBona G. F. Effect of ureteral clamping and increased renal arterial pressure on renin release. Am J Physiol. 1973 Jul;225(1):95–99. doi: 10.1152/ajplegacy.1973.225.1.95. [DOI] [PubMed] [Google Scholar]
  11. Ludens J. H., Heitz D. C., Brody M. J., Williamson H. E. Differential effect of furosemide on renal and limb blood flows in the conscious dog. J Pharmacol Exp Ther. 1970 Feb;171(2):300–306. [PubMed] [Google Scholar]
  12. Ludens J. H., Hook J. B., Brody M. J., Williamson H. E. Enhancement of renal blood flow by furosemide. J Pharmacol Exp Ther. 1968 Oct;163(2):456–460. [PubMed] [Google Scholar]
  13. Meyer P., Menard J., Papanicolaou N., Alexandre J. M., Devaux C., Milliez P. Mechanism of renin release following furosemide diuresis in rabbit. Am J Physiol. 1968 Oct;215(4):908–915. doi: 10.1152/ajplegacy.1968.215.4.908. [DOI] [PubMed] [Google Scholar]
  14. Rosenthal J., Boucher R., Nowaczynski W., Genest J. Acute changes in plasma volume, renin activity, and free aldosterone levels in healthy subjects following Fursemide administration. Can J Physiol Pharmacol. 1968 Jan;46(1):85–91. doi: 10.1139/y68-015. [DOI] [PubMed] [Google Scholar]
  15. SKINNER S. L., MCCUBBIN J. W., PAGE I. H. CONTROL OF RENIN SECRETION. Circ Res. 1964 Jul;15:64–76. doi: 10.1161/01.res.15.1.64. [DOI] [PubMed] [Google Scholar]
  16. Skinner S. L. Improved assay methods for renin "concentration" and "activity" in human plasma. Methods using selective denaturation of renin substrate. Circ Res. 1967 Apr;20(4):391–402. doi: 10.1161/01.res.20.4.391. [DOI] [PubMed] [Google Scholar]
  17. Van Dongen R., Peart W. S. Calcium dependence of the inhibitory effect of angiotensin on renin secretion in the isolated perfused kidney of the rat. Br J Pharmacol. 1974 Jan;50(1):125–129. doi: 10.1111/j.1476-5381.1974.tb09599.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Vander A. J., Carlson J. Mechanism of the effects of furosemide on renin secretion in anesthetized dogs. Circ Res. 1969 Aug;25(2):145–152. doi: 10.1161/01.res.25.2.145. [DOI] [PubMed] [Google Scholar]
  19. Vander A. J. Control of renin release. Physiol Rev. 1967 Jul;47(3):359–382. doi: 10.1152/physrev.1967.47.3.359. [DOI] [PubMed] [Google Scholar]
  20. Vander A. J., Luciano J. R. Effects of mercurial diuresis and acute sodium depletion on renin release in dog. Am J Physiol. 1967 Mar;212(3):651–656. doi: 10.1152/ajplegacy.1967.212.3.651. [DOI] [PubMed] [Google Scholar]
  21. Vandongen R., Greenwood D. M. The stimulation of renin secretion by diazoxide in the isolated rat kidney. Eur J Pharmacol. 1975 Aug;33(1):197–200. doi: 10.1016/0014-2999(75)90157-0. [DOI] [PubMed] [Google Scholar]
  22. Vandongen R., Greenwood D. M. The stimulation of renin secretion by non-vasocontrictor infusions of adrenaline and noradrenaline in the isolated rat kidney. Clin Sci Mol Med. 1975 Dec;49(6):609–612. doi: 10.1042/cs0490609. [DOI] [PubMed] [Google Scholar]
  23. Vandongen R., Peart W. S., Boyd G. W. Andrenergic stimulation of renin secretion in the isolated perfused rat kidney. Circ Res. 1973 Feb;32(2):290–296. doi: 10.1161/01.res.32.2.290. [DOI] [PubMed] [Google Scholar]
  24. Vandongen R., Peart W. S., Boyd G. W. Effect of angiotensin II and its nonpressor derivatives on renin secretion. Am J Physiol. 1974 Feb;226(2):277–282. doi: 10.1152/ajplegacy.1974.226.2.277. [DOI] [PubMed] [Google Scholar]
  25. Winer N., Chokshi D. S., Yoon M. S., Freedman A. D. Adrenergic receptor mediation of renin secretion. J Clin Endocrinol Metab. 1969 Sep;29(9):1168–1175. doi: 10.1210/jcem-29-9-1168. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES