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. 1976 Jul;57(3):387–393. doi: 10.1111/j.1476-5381.1976.tb07678.x

Effect of prostaglandin E1 on neuromuscular transmission in the rat.

J Gripenberg, S E Jansson, V Heinänen, E Heinonen, J Hyvärinen, E M Tolppanen
PMCID: PMC1667256  PMID: 184867

Abstract

1 The effect of prostaglandin E1 on neuromuscular transmission in the phrenic nerve-diaphragm muscle preparation of the rat was studied with intra- and extracellular recording techniques. 2 Prostaglandin E1, in concentrations from 10 nM, induced intermittent failures in the generation of the end-plate potential in response to repeated indirect stimulation. 3 Failures appeared abruptly, the end-plate potential behaving in an all-or-nothing fashion. The effect occurred only at 36-38 degrees C when the nerve was stimulated at 30-80 Hz and was reversible upon washing with drug-free solution. 4 Since miniature end-plate potentials were not affected, such failures must be attributed to a presynaptic action of prostaglandin E1. 5 Extracellular recording suggested that prostaglandin E1 prevented the action potential from reaching the nerve terminal.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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