Abstract
The protective effects of pretreatment with zinc sulphate aerosols against bronchoconstriction induced by egg albumen or histamine aerosols were assessed in sensitized or non-sensitized guinea-pigs respectively. Pretreatment with an adequate concentration of zinc sulphate aerosol significantly prolonged the time of onset of bronchoconstriction in sensitized guinea-pigs challenged with egg albumen, but did not appreciably alter the onset time of histamine-induced bronchoconstriction in non-sensitized animals. These findings suggest that zinc aerosols may be of prophylactic value against bronchoconstriction of allergic origin.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Assem E. S., Mongar J. L. Inhibition of allergic reactions in man and other species by cromoglycate. Int Arch Allergy Appl Immunol. 1970;38(1):68–77. doi: 10.1159/000230260. [DOI] [PubMed] [Google Scholar]
- Dykes M. H. Evaluation of an antiasthmatic agent cromolyn sodium (Aarane, Intal). JAMA. 1974 Mar 4;227(9):1061–1062. [PubMed] [Google Scholar]
- Garland L. G., Mongar J. L. Inhibition by cromoglycate of histamine release from rat peritoneal mast cells induced by mixtures of dextran, phosphatidyl serine and calcium ions. Br J Pharmacol. 1974 Jan;50(1):137–143. doi: 10.1111/j.1476-5381.1974.tb09601.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HERXHEIMER H. Repeatable micro-shocks of constant strength in guinea-pig anaphylaxis. J Physiol. 1952 Jun;117(2):251–255. doi: 10.1113/jphysiol.1952.sp004745. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HOGBERG B., UVNAS B. Further observations on the disruption of rat mesentery mast cells caused by compound 48/80, antigen-antibody reaction, lecithinase A and decylamine. Acta Physiol Scand. 1960 Mar 18;48:133–145. doi: 10.1111/j.1748-1716.1960.tb01853.x. [DOI] [PubMed] [Google Scholar]
- MOTA I., VUGMAN I. Effects of anaphylactic shock and compound 48/80 on the mast cells of the guinea pig lung. Nature. 1956 Mar 3;177(4505):427–429. doi: 10.1038/177427a0. [DOI] [PubMed] [Google Scholar]