Abstract
The rate of fluid reabsorption was studied in the rat isolated caudal epididymal sac in vitro. 2 Part of the fluid reabsorption was found to be dependent on intraluminal Na+. Amiloride (0.1 mM) completely inhibited this component of fluid reabsorption. 3 The log dose-inhibition curve to amiloride was sigmoid and the IC50 value was found to be 1.6 muM.
Full text
PDF![529](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f781/1667476/7052377ebca8/brjpharm00504-0053.png)
![530](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f781/1667476/586f09171e45/brjpharm00504-0054.png)
![531](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f781/1667476/77f8c99065ff/brjpharm00504-0055.png)
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Guignard J. P., Peters G. Effects of triamterene and amiloride on urinary acidification and potassium excretion in the rat. Eur J Pharmacol. 1970 May;10(2):255–267. doi: 10.1016/0014-2999(70)90281-5. [DOI] [PubMed] [Google Scholar]
- Levine N., Marsh D. J. Micropuncture studies of the electrochemical aspects of fluid and electrolyte transport in individual seminiferous tubules, the epididymis and the vas deferens in rats. J Physiol. 1971 Mar;213(3):557–570. doi: 10.1113/jphysiol.1971.sp009400. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schneyer L. H. Amiloride inhibition of ion transport in perfused excretory duct of rat submaxillary gland. Am J Physiol. 1970 Oct;219(4):1050–1055. doi: 10.1152/ajplegacy.1970.219.4.1050. [DOI] [PubMed] [Google Scholar]