Abstract
1 Electrical stimulation with trains of 0.1-0.2 ms pulses of the cat isolated sphincter of Oddi inhibited the spontaneous contractile activity and lowered base-line tension considerably. A contraction usually followed the period of stimulation. 2 These inhibitory effects were prevented by tetrodotoxin 0.1-0.5 mug/ml but were not reduced by hexamethonilm, morphine, or blockade of alpha- or beta-adrenoreceptors of cholinoceptors with phenoxy-benzamine propranolol or atropine, respectively. 3 Adenosine-5'-triphosphate (ATP) and adenosine-5'-diphosphate (ADP) inhibited the spontaneous sphincter activity and caused relaxation thus mimicking the effects of the C-terminal octapeptide of cholecystokinin (C8-CCK), isoprenaline and prostaglandin E1 and E2. 4 ATP alone (greater than 100 mug/ml) or ATP (greater than 10 mug/ml) plus dipyridamole (1 mug/ml), relaxed the sphincter to the same degrees as did the field stimulation. 5 In sphincter maximally contracted by acetylcholine, the effect of stimulation was more marked than that recorded in uncontracted preparations. 6 The present findings suggest that the sphincter of Oddi receives inhibitory nerves that are neither cholinergic nor adrenergic.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Andersson K. E., Andersson R., Hedner P., Persson C. G. Parallelism between mechanical and metabolic responses to cholecystokinin and prostaglandin E2 in extrahepatic biliary tract. Acta Physiol Scand. 1973 Dec;89(4):571–579. doi: 10.1111/j.1748-1716.1973.tb05551.x. [DOI] [PubMed] [Google Scholar]
- Bortoff A. Digestion: motility. Annu Rev Physiol. 1972;34:261–290. doi: 10.1146/annurev.ph.34.030172.001401. [DOI] [PubMed] [Google Scholar]
- Burnstock G., Cocks T., Paddle B., Staszewska-Barczak J. Evidence that prostaglandin is responsible for the 'rebound contraction' following stimulation of non-adrenergic, non-cholinergic ('purinergic') inhibitory nerves. Eur J Pharmacol. 1975 Apr;31(2):360–362. doi: 10.1016/0014-2999(75)90060-6. [DOI] [PubMed] [Google Scholar]
- Burnstock G. Purinergic nerves. Pharmacol Rev. 1972 Sep;24(3):509–581. [PubMed] [Google Scholar]
- Coleman R. A., Levy G. P. A non-adrenergic inhibitory nervous pathway in guinea-pig trachea. Br J Pharmacol. 1974 Oct;52(2):167–174. doi: 10.1111/j.1476-5381.1974.tb09697.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Furness J. B. Secondary excitation of intestinal smooth muscle. Br J Pharmacol. 1971 Feb;41(2):213–226. doi: 10.1111/j.1476-5381.1971.tb08023.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Persson C. G. Adrenoceptor functions in the cat choledochoduodenal junction in vitro. Br J Pharmacol. 1971 Jul;42(3):447–461. doi: 10.1111/j.1476-5381.1971.tb07130.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Persson C. G. Excitatory effect of tetrodotoxin on an isolated smooth muscle organ. J Pharm Pharmacol. 1971 Dec;23(12):986–987. doi: 10.1111/j.2042-7158.1971.tb09914.x. [DOI] [PubMed] [Google Scholar]