Skip to main content
NCBI home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1977 Oct;61(2):315–317. doi: 10.1111/j.1476-5381.1977.tb08421.x

The antidysrhythmic aminosteroid, ORG 6001, reduces the ST-segment elevation produced by coronary occlusion in the dog.

R J Marshall, J R Parratt
PMCID: PMC1667497  PMID: 922260

Abstract

ST-segment elevation following temporary coronary artery occlusion was measured from nine epicardial leads in open-chest anaesthetized dogs. This was greatly reduced by the prior administration of the anti-dysrhythmic aminosteroid, ORG 6001. It is suggested that this effect is related either to a reduction in the extent and degree of myocardial ischaemia or to prevention of K+ egress from ischaemic cells.

Full text

PDF
315

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cohen D., Kaufman L. A. Magnetic determination of the relationship between the S-T segment shift and the injury current produced by coronary artery occlusion. Circ Res. 1975 Mar;36(3):414–424. doi: 10.1161/01.res.36.3.414. [DOI] [PubMed] [Google Scholar]
  2. Fozzard H. A., DasGupta D. S. ST-segment potentials and mapping. Theory and experiments. Circulation. 1976 Oct;54(4):533–537. doi: 10.1161/01.cir.54.4.533. [DOI] [PubMed] [Google Scholar]
  3. Karlsson J., Templeton G. H., Willerson J. T. Relationship between epicardial S-T segment changes and myocardial metabolism during acute coronary insufficiency. Circ Res. 1973 Jun;32(6):725–730. doi: 10.1161/01.res.32.6.725. [DOI] [PubMed] [Google Scholar]
  4. Maroko P. R., Kjekshus J. K., Sobel B. E., Watanabe T., Covell J. W., Ross J., Jr, Braunwald E. Factors influencing infarct size following experimental coronary artery occlusions. Circulation. 1971 Jan;43(1):67–82. doi: 10.1161/01.cir.43.1.67. [DOI] [PubMed] [Google Scholar]
  5. Marshall R. J., Parratt J. R. Antiarrhythmic, haemodynamic and metabolic effects of 3alpha-amino-5alpha-androstan-2beta-ol-17-one hydrochloride in greyhounds following acute coronary artery ligation. Br J Pharmacol. 1975 Nov;55(3):359–368. doi: 10.1111/j.1476-5381.1975.tb06939.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Marshall R. J., Parratt J. R., Ledingham I. M. Changes in blood flow and oxygen consumption in normal and ischaemic regions of the myocardium following acute coronary artery ligation. Cardiovasc Res. 1974 Mar;8(2):204–215. doi: 10.1093/cvr/8.2.204. [DOI] [PubMed] [Google Scholar]
  7. Marshall R. J., Parratt J. R. The haemodynamic and metabolic effects of MG 8926, a prospective antidysrhythmic and antianginal agent. Br J Pharmacol. 1977 Feb;59(2):311–322. doi: 10.1111/j.1476-5381.1977.tb07494.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Roberts R., Husain A., Ambos H. D., Oliver G. C., Cox J. R., Jr, Sobel B. E. Relation between infarct size and ventricular arrhythmia. Br Heart J. 1975 Nov;37(11):1169–1175. doi: 10.1136/hrt.37.11.1169. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Salako L. A., Williams V., Wittig J. H. Investigations to characterize a new anti-arrhythmic drug, ORG 6001 including a simple test for calcium antagonism. Br J Pharmacol. 1976 Jun;57(2):251–262. doi: 10.1111/j.1476-5381.1976.tb07475.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Smith H. J., Singh B. N., Nisbet H. D., Norris R. M. Effects of verapamil on infarct size following experimental coronary occlusion. Cardiovasc Res. 1975 Jul;9(4):569–578. doi: 10.1093/cvr/9.4.569. [DOI] [PubMed] [Google Scholar]
  11. Wendt R. L., Canavan R. C., Michalak R. J. Effects of various agents on regional ischemic myocardial injury: electrocardiographic analysis. Am Heart J. 1974 Apr;87(4):468–482. doi: 10.1016/0002-8703(74)90172-0. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES