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. 1977 Sep;61(1):87–89. doi: 10.1111/j.1476-5381.1977.tb09743.x

Inhibition by a stable analogue of adenosine triphosphate of platelet aggregation by adenosine diphosphate.

G V Born, J G Foulks
PMCID: PMC1667631  PMID: 912211

Abstract

1 In citrated platelet-rich plasma, freshly prepared from rabbit blood, the velocity of platelet aggregation was within limits proportional to the log of the concentration of added adenosine diphosphate (ADP). 2 Addition of either adenosine triphosphate (ATP) or its beta,y-methylene analogue inhibited aggregation similarly except that the analogue was about half as potent as ATP. beta,y-Methylene ATP also reversed the optical effects associated with the shape change of platelets very similarly to ATP itself. 3 As beta,y-methylene ATP is not a substrate for nucleoside diphosphokinase, these observations do not support the proposition that inhibition of aggregation by added ATP is due to its utilization by the nucleoside diphosphokinase of platelets.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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