Abstract
1 Histamine and 2-methyl-histamine (H1-receptor agonist) caused dose-dependent increases in capillary permeability in albino mice, but 4-methyl-histamine (H2-receptor agonist) caused no significant increase. 2 Mepyramine (H1-receptor antagonist) blocked the histamine-induced increase in capillary permeability whereas burimamide (H2-receptor antagonist) produced no significant blockade of the histamine-response. 3 Combined mepyramine and burimamide pretreatment did not give any significantly greater protection than mepyramine alone. 4 The results indicate involvement of the H1-receptors in histamine-induced increase in capillary permeability.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Black J. W., Duncan W. A., Durant C. J., Ganellin C. R., Parsons E. M. Definition and antagonism of histamine H 2 -receptors. Nature. 1972 Apr 21;236(5347):385–390. doi: 10.1038/236385a0. [DOI] [PubMed] [Google Scholar]
- Dale H. H., Richards A. N. The vasodilator action of histamine and of some other substances. J Physiol. 1918 Jul 10;52(2-3):110–165. doi: 10.1113/jphysiol.1918.sp001825. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dekanski J. The effect of severe burns and some protein-precipitants on skin-histamine in cats. J Physiol. 1947 Mar 15;106(1):33–41. [PMC free article] [PubMed] [Google Scholar]
- GADDUM J. H. Histamine. Br Med J. 1948 May 8;1(4557):867–873. doi: 10.1136/bmj.1.4557.867. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Macaraeg P. V., Jr, Bianchine J. R., Lasagna L. Tolerance to drug-induced writhing in mice. J Pharmacol Exp Ther. 1968 May;161(1):130–140. [PubMed] [Google Scholar]
- Maling H. M., Webster M. E., Williams M. A., Saul W., Anderson W., Jr Inflammation induced by histamine, serotonin, bradykinin and compound 48-80 in the rat: antagonists and mechanisms of action. J Pharmacol Exp Ther. 1974 Nov;191(2):300–310. [PubMed] [Google Scholar]
- WHITTLE B. A. THE USE OF CHANGES IN CAPILLARY PERMEABILITY IN MICE TO DISTINGUISH BETWEEN NARCOTIC AND NONNARCOTIC ALALGESICS. Br J Pharmacol Chemother. 1964 Apr;22:246–253. doi: 10.1111/j.1476-5381.1964.tb02030.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WILHELM D. L. The mediation of increased vascular permeability in inflammation. Pharmacol Rev. 1962 Jun;14:251–280. [PubMed] [Google Scholar]