Abstract
1. delta9-Tetrahydrocannabinol and cannabidiol both exhibited a concentration-related inhibition of Mg2+-ATPase of vesicles prepared from synaptosomes isolated from rat cerebral cortex. Cannabidiol was about 3 times more potent than tetrahydrocannabinol. 2. These results were similar to those obtained previously using drugs with well established anticonvulsant activity. 3. Tetrahydrocannabinol at a sub-inhibitory concentration (1 micronM) increased the activity of the Mg2+-ATPase relative to values obtained with vehicle controls.
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- BONTING S. L., SIMON K. A., HAWKINS N. M. Studies on sodium-potassium-activated adenosine triphosphatase. I. Quantitative distribution in several tissues of the cat. Arch Biochem Biophys. 1961 Dec;95:416–423. doi: 10.1016/0003-9861(61)90170-9. [DOI] [PubMed] [Google Scholar]
- GRAY E. G., WHITTAKER V. P. The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation. J Anat. 1962 Jan;96:79–88. [PMC free article] [PubMed] [Google Scholar]
- Gilbert J. C., Wyllie M. G. Effects of anticonvulsant and convulsant drugs on the ATPase activities of synaptosomes and their components. Br J Pharmacol. 1976 Jan;56(1):49–57. doi: 10.1111/j.1476-5381.1976.tb06958.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gilbert J. C., Wyllie M. G. Proceedings: Synaptic vesicle magnesium-adenosine triphosphatase as a possible site of action of anticonvulsant drugs. Br J Pharmacol. 1975 Oct;55(2):252P–252P. [PMC free article] [PubMed] [Google Scholar]
- Izquierdo I., Orsingher O. A., Berardi A. C. Effect of cannabidiol and of other cannabis sativa compounds on hippocampal seizure discharges. Psychopharmacologia. 1973;28(1):95–102. doi: 10.1007/BF00413961. [DOI] [PubMed] [Google Scholar]
- Karler R., Cely W., Turkanis S. A. The anticonvulsant activity of cannabidiol and cannabinol. Life Sci. 1973 Dec 1;13(11):1527–1531. doi: 10.1016/0024-3205(73)90141-0. [DOI] [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- Whittaker V. P., Michaelson I. A., Kirkland R. J. The separation of synaptic vesicles from nerve-ending particles ('synaptosomes'). Biochem J. 1964 Feb;90(2):293–303. doi: 10.1042/bj0900293. [DOI] [PMC free article] [PubMed] [Google Scholar]