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. 1978 Jan;62(1):75–78. doi: 10.1111/j.1476-5381.1978.tb07008.x

Reversal of guanethidine blockade of sympathetic nerve terminals by tetraethylammonium and 4-aminopyridine.

M Kirpekar, S M Kirpekar, J C Prat
PMCID: PMC1667782  PMID: 620099

Abstract

1 The effect of tetraethylammonium (TEA) and 4-aminopyridine (4-AP) on the inhibitory effect of guanethidine on noradrenaline (NA) release was investigated in the perfused spleen of the cat. 2 Guanethidine blocked the release of NA evoked by nerve stimulation. TEA and 4-AP readily reversed this inhibitory effect, and the NA output was nearly doubled after repeated stimulation of the nerves. On subsequent perfusion with Krebs solution without TEA or 4-AP, the inhibitory effect of guanethidine reappeared. 3 The reversal of guanethidine blockade of sympathetic nerves by TEA and 4-AP is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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