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. 1978 Jan;62(1):107–113. doi: 10.1111/j.1476-5381.1978.tb07012.x

The effects of glycerol detubulation, of manganese ions, of dantrolene and of nitrate ions on the responses of isolated chronically denervated soleus muscles of the mouse to acetylcholine.

M T Hall, M A Maleque, R M Wadsworth
PMCID: PMC1667786  PMID: 620091

Abstract

1 In the isolated chronically denervated soleus muscle of the mouse acetylcholine produced a biphasic contraction. 2 In muscles detubulated by glycerol treatment, the first phase of the acetylcholine contraction was almost abolished, but the second was only slightly reduced or was unaffected. 3 Manganese ions (10 mM) reduced the first phase of the acetylcholine response, but enhanced the second. 4 Dantrolene sodium (5.94 x 10(-5) M) reduced the first phase of the acetylcholine response, but not the second. 5 Nitrate ions (118 mM) augmented the first phase but not the second. 6 It was concluded that the first phase requires the excitation-contraction-coupling sequence: membrane depolarization-T-tubules-Ca2+ release from sarcoplasmic reticulum. In contrast, the second phase appears to occur independently of these processes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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