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. 1978 Feb;62(2):195–198. doi: 10.1111/j.1476-5381.1978.tb08445.x

Enhancement by oxotremorine of acetylcholine release from the rat phrenic nerve.

M Das, D K Ganguly, J R Vedasiromoni
PMCID: PMC1667799  PMID: 203356

Abstract

Oxotremorine (10.5 micron) produced a paralytic effect on twitch responses of rat diaphragm in vitro to direct and indirect stimulation. 2 The paralytic effect of oxotremorine was absent when the diaphragm was stimulated directly in the presence of hemicholinium-3 (0.42 mM), at a time when twitch responses to indirect stimulation ceased completely. 3 Oxotremorine, at two different pharmacologically active doses, strikingly increased the resting as well as electrically evoked release of acetylcholine into the bathing fluid from the phrenic nerve-diaphragm preparation. 4 This presynaptic effect of oxotremorine may explain its pharmacological effects at the cholinergic synapses studied so far.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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