Abstract
1. Intravenous administration of both the 9alpha,11alpha-(epoxymethano) and 11alpha,9alpha-(epoxymethano) analogues of prostaglandin H2 (0.25 microgram/kg) produced a prominent rise in pulmonary arterial pressure and a moderate increase in systemic arterial pressure. 2. Direct administration of the endoperoxide analogues (1.25 microgram/kg) into the bypass reservoir produced a greater rise in systemic arterial pressure and less prominent rise in pulmonary arterial pressure. 3. An intravenous dose of prostaglandin F2alpha that was 20 times larger was needed to produce a comparable rise in pulmonary arterial pressure. 4. The pulmonary and systemic pressor responses produced by the endoperoxide analogues were due to a direct increase in the vascular resistance.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Hamberg M., Hedqvist P., Strandberg K., Svensson J., Samuelsson B. Prostaglandin endoperoxides IV. Effects on smooth muscle. Life Sci. 1975 Feb 1;16(3):451–462. doi: 10.1016/0024-3205(75)90266-0. [DOI] [PubMed] [Google Scholar]
- Hamberg M., Svensson J., Wakabayashi T., Samuelsson B. Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation. Proc Natl Acad Sci U S A. 1974 Feb;71(2):345–349. doi: 10.1073/pnas.71.2.345. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kot P. A., Johnson M., Ramwell P. W., Rose J. C. Effects of ganglionic and beta-adrenergic blockade on cardiovascular responses to the bisenoic prostaglandins and their precursor arachidonic acid. Proc Soc Exp Biol Med. 1975 Sep;149(4):953–957. doi: 10.3181/00379727-149-38934. [DOI] [PubMed] [Google Scholar]
- Needleman P., Minkes M., Raz A. Thromboxanes: selective biosynthesis and distinct biological properties. Science. 1976 Jul 9;193(4248):163–165. doi: 10.1126/science.945611. [DOI] [PubMed] [Google Scholar]
- ROSE J. C., BROIDA H. P., HUFNAGEL C. A., GILLESPIE J. F., RABILE P. J., FREIS E. D. A method for the study of the circulation in the dog using a mechanical left ventricle. J Appl Physiol. 1955 Mar;7(5):580–584. doi: 10.1152/jappl.1955.7.5.580. [DOI] [PubMed] [Google Scholar]
- Rose J. C., Johnson M., Ramwell P. W., Kot P. A. Effects of arachidonic acid on systemic arterial pressure, myocardial contractility and platelets in the dog. Proc Soc Exp Biol Med. 1974 Dec;147(3):652–655. doi: 10.3181/00379727-147-38408. [DOI] [PubMed] [Google Scholar]
- Rose J. C., Kot A., Ramwell W., Doykos M., O'Neill W. P. Cardiovascular responses to three prostaglandin endoperoxide analogs in the dog. Proc Soc Exp Biol Med. 1976 Nov;153(2):209–212. doi: 10.3181/00379727-153-39512. [DOI] [PubMed] [Google Scholar]
- Wicks T. C., Rose J. C., Johnson M., Ramwell P. W., Kot P. A. Vascular responses to arachidonic acid in the perfused canine lung. Circ Res. 1976 Mar;38(3):167–171. doi: 10.1161/01.res.38.3.167. [DOI] [PubMed] [Google Scholar]