Abstract
1. Direct observations were made of the rat mesenteric vasculature in vivo. They showed a gradual increase in the sensitivity to topically applied noradrenaline from the larger arteries to the precapillary arterioles which was paralleled by a gradual decrease in the density of the adrenergic innervation. 2. Both cocaine and chronic denervation increased the sensitivity to noradrenaline of the innervated arterial vessels, approximately in proportion to the density to their innervation. They did not affect the sensitivity of the non-innervated precapillary arterioles. 3. It is concluded that the sensitivity gradient to topically applied noradrenaline results mainly from the uptake of the applied catecholamine by the perivascular nerve terminals.
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Selected References
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- Altura B. M. Evaluation of neurohumoral substances in local regulation of blood flow. Am J Physiol. 1967 Jun;212(6):1447–1454. doi: 10.1152/ajplegacy.1967.212.6.1447. [DOI] [PubMed] [Google Scholar]
- BAEZ S. Response characteristics of perfused microvessels to pressure and vasoactive stimuli. Angiology. 1961 Oct;12:452–461. doi: 10.1177/000331976101201004. [DOI] [PubMed] [Google Scholar]
- Bevan J. A., Verity M. A. Sympathetic nerve-free vascular muscle. J Pharmacol Exp Ther. 1967 Jul;157(1):117–124. [PubMed] [Google Scholar]
- De La Lande I. S., Waterson J. G. Site of action of cocaine on the perfused artery. Nature. 1967 Apr 15;214(5085):313–314. doi: 10.1038/214313a0. [DOI] [PubMed] [Google Scholar]
- Furness J. B., Malmfors T. Aspects of the arrangement of the adrenergic innervation in guinea-pig as revealed by the fluorescence histochemical method applied to stretched, air-dried preparations. Histochemie. 1971;25(4):297–309. doi: 10.1007/BF00278223. [DOI] [PubMed] [Google Scholar]
- Furness J. B., Marshall J. M. Correlation of the directly observed responses of mesenteric vessles of the rat to nerve stimulation and noradrenaline with the distribution of adrenergic nerves. J Physiol. 1974 May;239(1):75–88. doi: 10.1113/jphysiol.1974.sp010556. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gore R. W. Wall stress: a determinant of regional differences in response of frog microvessels to norepinephrine. Am J Physiol. 1972 Jan;222(1):82–91. doi: 10.1152/ajplegacy.1972.222.1.82. [DOI] [PubMed] [Google Scholar]
- Kalsner S., Nickerson M. Mechanism of cocaine potentiation of responses to amines. Br J Pharmacol. 1969 Mar;35(3):428–439. doi: 10.1111/j.1476-5381.1969.tb08284.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rodigas P., Cession-Fossion A. Evolution de la catécholaminémie, lors de la saignée, chez le rat éveillé. C R Seances Soc Biol Fil. 1972;166(4):747–749. [PubMed] [Google Scholar]
- Trendelenburg U. Mechanisms of supersensitivity and subsensitivity to sympathomimetic amines. Pharmacol Rev. 1966 Mar;18(1):629–640. [PubMed] [Google Scholar]