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. 1978 Apr;62(4):519–528. doi: 10.1111/j.1476-5381.1978.tb07756.x

Investigation of the role of histamine in antigen-induced bronchoconstriction in the ascaris-hypersensitive dog.

R D Krell
PMCID: PMC1668037  PMID: 26444

Abstract

1 Aerosol administration of ascaris antigen to the airways of ascaris-hypersensitive dogs provoked increases in pulmonary resistance (Rp) and decreases in dynamic lung compliance (Cdyn). These changes in pulmonary mechanics were not inhibited by the histamine H1-receptor antagonists, diphenhydramine or mepyramine. 2 Increases in Rp and decreases in Cdyn induced by a histamine aerosol were markedly or totally inhibited by comparable doses of these H1-antihistamines. 3 Doses of antigen which produced pathophysiological pulmonary responses failed to produce a detectable histamine release from the cardiopulmonary system in vivo. Aerosol antigen provocation, equivalent to 5 to 9 times greater than that which produced substantial pathophysiological pulmonary responses, did cause histamine release in vivo. 4 The canine cardiopulmonary system showed only a modest ability to remove and/or degrade circulating histamine. 5 It is concluded that histamine may not play a major role in mediating the acute antigen-induced bronchoconstriction in the ascaris-hypersensitive dog.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Black J. W., Duncan W. A., Emmett J. C., Ganellin C. R., Hesselbo T., Parsons M. E., Wyllie J. H. Metiamide--an orally active histamine H2-receptor antagonist. Agents Actions. 1973 Oct;3(3):133–137. doi: 10.1007/BF01965723. [DOI] [PubMed] [Google Scholar]
  2. Booth B. H., Patterson R., Talbot C. H. Immediate-type hypersensitivity in dogs: cutaneous, anaphylactic, and respiratory responses to ascaris. J Lab Clin Med. 1970 Aug;76(2):181–189. [PubMed] [Google Scholar]
  3. Chiesa A., Dain D., Meyers G. L., Kessler G. F., Gold W. M. Histamine release during antigen inhalation in experimental asthma in dogs. Am Rev Respir Dis. 1975 Feb;111(2):148–156. doi: 10.1164/arrd.1975.111.2.148. [DOI] [PubMed] [Google Scholar]
  4. DALE H. Antihistamine substances. Br Med J. 1948 Aug 7;2(4570):281–283. doi: 10.1136/bmj.2.4570.281. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Ferreira S. H., Ng K. K., Vane J. R. The continuous bioassay of the release and disappearance of histamine in the circulation. Br J Pharmacol. 1973 Nov;49(3):543–553. doi: 10.1111/j.1476-5381.1973.tb17265.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gold W. M., Kessler G. F., Yu D. Y., Frick O. L. Pulmonary physiologic abnormalities in experimental asthma in dogs. J Appl Physiol. 1972 Oct;33(4):496–501. doi: 10.1152/jappl.1972.33.4.496. [DOI] [PubMed] [Google Scholar]
  7. Kessler G. F., Frick O. L., Gold W. M. Immunologic and physiologic characterization of the role of reaginic antibodies in experimental asthma in dogs. Int Arch Allergy Appl Immunol. 1974;47(3):313–328. doi: 10.1159/000231225. [DOI] [PubMed] [Google Scholar]
  8. Krell R. D., Chakrin L. W. An in vitro model of canine immediate-type hypersensitivity reactions. Int Arch Allergy Appl Immunol. 1976;51(6):641–655. doi: 10.1159/000231643. [DOI] [PubMed] [Google Scholar]
  9. Krell R. D., Chakrin L. W., Christian P., Giannone E., McCoy J., Osborn R. Canine airway responses to acetylcholine, prostaglandin F2alpha, histamine, and serotonin after chronic antigen exposure. J Allergy Clin Immunol. 1976 Dec;58(6):664–675. doi: 10.1016/0091-6749(76)90178-0. [DOI] [PubMed] [Google Scholar]
  10. Krell R. D., Chakrin L. W. Pharmacologic regulation of antigen-induced mediator release from canine lung. Int Arch Allergy Appl Immunol. 1978;56(1):39–47. doi: 10.1159/000232001. [DOI] [PubMed] [Google Scholar]
  11. Krell R. D., Chakrin L. W., Wardell J. R., Jr The effect of cholinergic agents on a canine model of allergic asthma. J Allergy Clin Immunol. 1976 Jul;58(1 Pt 1):19–30. doi: 10.1016/0091-6749(76)90103-2. [DOI] [PubMed] [Google Scholar]
  12. PATTERSON R., SPARKS D. B. The passive transfer to normal dogs of skin reactivity, asthma and anaphylaxis from a dog with spontaneous ragweed pollen hypersensitivity. J Immunol. 1962 Feb;88:262–268. [PubMed] [Google Scholar]
  13. Patterson R., Mellies C. J., Kelly J. F., Harris K. E. Airway responses of dogs with ragweed and ascaris hypersensitivity. Chest. 1974 May;65(5):488–492. doi: 10.1378/chest.65.5.488. [DOI] [PubMed] [Google Scholar]
  14. Rosenthal R. R., Norman P. S., Summer W. R. Bronchoprovocation: effect on priming and desensitization phenomenon in the lung. J Allergy Clin Immunol. 1975 Nov;56(5):338–346. doi: 10.1016/0091-6749(75)90127-x. [DOI] [PubMed] [Google Scholar]
  15. Schwartzman R. M., Rockey J. H., Halliwell R. E. Canine reaginic antibody. Characterization of the spontaneous anti-ragweed and induced anti-dinitrophenyl reaginic antibodies of the atopic dog. Clin Exp Immunol. 1971 Nov;9(5):549–569. [PMC free article] [PubMed] [Google Scholar]
  16. Taylor K. M., Snyder S. H. Isotopic microassay of histamine, histidine, histidine decarboxylase and histamine methyltransferase in brain tissue. J Neurochem. 1972 May;19(5):1343–1358. doi: 10.1111/j.1471-4159.1972.tb01459.x. [DOI] [PubMed] [Google Scholar]
  17. Yu D. Y., Galant S. P., Gold W. M. Inhibition of antigen-induced bronchoconstriction by atropine in asthmatic patients. J Appl Physiol. 1972 Jun;32(6):823–828. doi: 10.1152/jappl.1972.32.6.823. [DOI] [PubMed] [Google Scholar]

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