Abstract
1 The isolated vas deferens of the rat was used to examine the peripheral action of oxypertine, a psychotropic-anxiolytic drug. 2 Oxypertine (4.4 X 10(-10) M to 2.6 X 10(-5) M) antagonized competitively the effects of noradrenaline (pA2 = 7.2), 5-hydroxytryptamine (pA2 = 8.6) and dopamine (pA2 = 9.8). 3 Oxypertine (8.8 X 10(-9) M to 2.6 X 10(-5) M) antagonized the effects of low concentrations of acetylcholine and enhanced the contractions elicited by high concentrations of acetylcholine. 4 The contractions evoked by transmural stimulation of the vas deferens were reduced by oxypertine. 5 Oxypertine failed to antagonize the responses to potassium chloride. 6 These findings are compared with the effects of other antidepressant drugs.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Benesová O., Náhunek K. Correlation between the experimental data from animal studies and therapetical effects of antidepressant drugs. Psychopharmacologia. 1971;20(4):337–347. doi: 10.1007/BF00403565. [DOI] [PubMed] [Google Scholar]
- Boadle-Biber M. C., Roth R. H. Formation of dopamine and noradrenaline in rat vas deferens: comparison with guinea-pig vas deferens. Br J Pharmacol. 1975 Sep;55(1):73–78. doi: 10.1111/j.1476-5381.1975.tb07613.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bonn J. A., Salkind M. R., Rees W. L. A technique in the evaluation of psychotropic medication based on a patient demand schedule: comparison of the efficacy of oxypertine, diazepam and placebo in anxiety. Curr Ther Res Clin Exp. 1971 Sep;13(9):561–567. [PubMed] [Google Scholar]
- Miranda H. Vas deferens desensitization by noradrenaline and other drugs. Arch Int Pharmacodyn Ther. 1976 Jun;221(2):223–234. [PubMed] [Google Scholar]
- Penn R. G. The basic pharmacology of oxypertine. Postgrad Med J. 1972 Sep;48(4 Suppl):7–11. [PubMed] [Google Scholar]
- Simon A., Van Maanen E. F. Dopamine receptors and dopaminergic nerves in the vas deferens of the rat. Arch Int Pharmacodyn Ther. 1976 Jul;222(1):4–15. [PubMed] [Google Scholar]
- Van Dorsser W., Dresse A. Effects comparés de divers antidepresseurs sur la réponse à la noradrénaline du canal déférent et de la pression artérielle, et sur la réponse à la 5-hydroxytryptamine de l'utérus de rat. Arch Int Pharmacodyn Ther. 1974 Apr;208(2):373–376. [PubMed] [Google Scholar]
- Vogt M. Functional aspects of the role of catecholamines in the central nervous system. Br Med Bull. 1973 May;29(2):168–172. doi: 10.1093/oxfordjournals.bmb.a070989. [DOI] [PubMed] [Google Scholar]
- Westfall D. P. Antagonism by protriptyline and desipramine of the response of the vas deferens of the rat to norepinephrine, acetylcholine and potassium. J Pharmacol Exp Ther. 1973 Jun;185(3):540–550. [PubMed] [Google Scholar]