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. 1977 Dec;61(4):669–677. doi: 10.1111/j.1476-5381.1977.tb07560.x

Comparative potencies of amphetamine, fenfluramine and related compounds in taste aversion experiments in rats

DA Booth, CWT Pilcher, GD D'Mello, IP Stolerman
PMCID: PMC1668069  PMID: 597669

Abstract

1 Rats failed to drink a flavoured solution when its consumption had been followed by injection of amphetamine (conditioned taste aversion).

2 There was very little difference between the potencies of (+)- and (-)-amphetamine.

3 p-Chloromethamphetamine was a more potent aversive agent than methamphetamine.

4 Strong taste aversions were also conditioned with other congeners of amphetamine. The rank order of potency was: fenfluramine > chlorphentermine >p-hydroxyamphetamine.

5 Cocaine induced only moderate taste aversions, even at high doses.

6 Aversive potency did not appear to be correlated with known neurochemical actions of the drugs or with behavioural stimulation, but appeared to be a central action which may have been linked to anorexigenic potency or time course of action.

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Selected References

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