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. 1978 Jul;63(3):503–507. doi: 10.1111/j.1476-5381.1978.tb07804.x

Effects of gamma-aminobutyric acid on nerve terminal excitability in a slice preparation of cuneate nucleus.

A G Hayes, M A Simmonds
PMCID: PMC1668099  PMID: 667494

Abstract

1 Superfusion of a slice preparation of the rat cuneate nucleus with gamma-aminobutyric acid (GABA) depolarized the afferent nerve fibres and increased their excitability. However, before the depolarization had reached its peak the increased excitability reversed to a decreased excitability, an effect which outlasted the depolarization. 2 Both components of the GABA excitability response were dose-related Cl--dependent and antagonized by bicuculline. 3 Possible mechanisms underlying the sequence of excitability changes are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDERSEN P., ECCLES J. C., SCHMIDT R. F., YOKOTA T. DEPOLARIZATION OF PRESYNAPTIC FIBERS IN THE CUNEATE NUCLEUS. J Neurophysiol. 1964 Jan;27:92–106. doi: 10.1152/jn.1964.27.1.92. [DOI] [PubMed] [Google Scholar]
  2. Adams P. R., Brown D. A. Actions of gamma-aminobutyric acid on sympathetic ganglion cells. J Physiol. 1975 Aug;250(1):85–120. doi: 10.1113/jphysiol.1975.sp011044. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Banna N. R., Jabbur S. J. Pharmacological studies on inhibition in the cuneate nucleus of the cat. Int J Neuropharmacol. 1969 May;8(3):299–307. doi: 10.1016/0028-3908(69)90051-3. [DOI] [PubMed] [Google Scholar]
  4. Banna N. R., Naccache A., Jabbur S. J. Picrotoxin-like action of bicuculline. Eur J Pharmacol. 1972 Feb;17(2):301–302. doi: 10.1016/0014-2999(72)90175-6. [DOI] [PubMed] [Google Scholar]
  5. Barker J. L., Nicoll R. A. Gamma-aminobutyric acid: role in primary afferent depolarization. Science. 1972 Jun 2;176(4038):1043–1045. doi: 10.1126/science.176.4038.1043. [DOI] [PubMed] [Google Scholar]
  6. Courtice C. J. A circuit for recording evoked action potential amplitudes [proceedings]. J Physiol. 1977 Jun;268(1):1P–2P. [PMC free article] [PubMed] [Google Scholar]
  7. Curtis D. R., Lodge D., Brand S. J. GABA and spinal afferent terminal excitability in the cat. Brain Res. 1977 Jul 15;130(2):360–363. doi: 10.1016/0006-8993(77)90283-9. [DOI] [PubMed] [Google Scholar]
  8. Davidson N., Southwick C. A. Amino acids and presynaptic inhibition in the rat cuneate nucleus. J Physiol. 1971 Dec;219(3):689–708. doi: 10.1113/jphysiol.1971.sp009683. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. De Groat W. C., Lalley P. M., Saum W. R. Depolarization of dorsal root ganglia in the cat by GABA and related amino acids: antagonism by picrotoxin and bicuculline. Brain Res. 1972 Sep 15;44(1):273–277. doi: 10.1016/0006-8993(72)90383-6. [DOI] [PubMed] [Google Scholar]
  10. Deschenes M., Feltz P., Lamour Y. A model for an estimate in vivo of the ionic basis of presynaptic inhibition: an intracellular analysis of the GABA-induced depolarization in rat dorsal root ganglia. Brain Res. 1976 Dec 24;118(3):486–493. doi: 10.1016/0006-8993(76)90318-8. [DOI] [PubMed] [Google Scholar]
  11. Hayes A. G., Gartside I. B., Straughan D. W. Effect of four convulsants on the time course of presynaptic inhibition and the relation to seizure activity. Neuropharmacology. 1977 Nov;16(11):725–730. doi: 10.1016/0028-3908(77)90129-0. [DOI] [PubMed] [Google Scholar]
  12. Lawson S. N., Biscoe T. J., Headley P. M. The effect of electrophoretically applied GABA on cultured dissociated spinal cord and sensory ganglion neurones of the rat. Brain Res. 1976 Dec 3;117(3):493–497. doi: 10.1016/0006-8993(76)90755-1. [DOI] [PubMed] [Google Scholar]
  13. Levy R. A., Anderson E. G. The effect of the GABA antagonists bicuculline and picrotoxin on primary afferent terminal excitability. Brain Res. 1972 Aug 11;43(1):171–180. doi: 10.1016/0006-8993(72)90282-x. [DOI] [PubMed] [Google Scholar]
  14. Nishi S., Minota S., Karczmar A. G. Primary afferent neurones: the ionic mechanism of GABA-mediated depolarization. Neuropharmacology. 1974 Mar;13(3):215–219. doi: 10.1016/0028-3908(74)90110-5. [DOI] [PubMed] [Google Scholar]
  15. SCHMIDT R. F. PHARMACOLOGICAL STUDIES ON THE PRIMARY AFFERENT DEPOLARIZATION OF THE TOAD SPINAL CORD. Pflugers Arch Gesamte Physiol Menschen Tiere. 1963 Jul 2;277:325–346. doi: 10.1007/BF00362515. [DOI] [PubMed] [Google Scholar]
  16. Simmonds M. A. Presynaptic actions of gamma-aminobutyric acid and some antagonists in a slice preparation of cuneate nucleus. Br J Pharmacol. 1978 Jul;63(3):495–502. doi: 10.1111/j.1476-5381.1978.tb07803.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

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